A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

T cell differentiation is governed by interactions with thymic epithelial cells (TECs) and defects in this process undermine immune function and tolerance. To uncover new strategies to restore thymic function and adaptive immunity in immunodeficiency, we sought to determine the molecular mechanisms...

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Bibliographic Details
Main Authors:	Jain, R, Sheridan, J, Policheni, A, Heinlein, M, Gandolfo, L, Dewson, G, Smyth, G, Sansom, S, Fu, N, Visvander, J, Hollander, G, Strasser, A, Gray, D
Format:	Journal article
Published:	American Society of Hematology 2017

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