Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates.
BACKGROUND: Aberrant social behavior is a defining symptom of frontotemporal dementia (FTD) and may eventually occur in all syndromes composing the FTD spectrum. Two main behavioral abnormalities have been described: apathy and disinhibition, but their neuroanatomical correlates remain underspecifi...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826260301094322176 |
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| author | Zamboni, G Huey, E Krueger, F Nichelli, P Grafman, J |
| author_facet | Zamboni, G Huey, E Krueger, F Nichelli, P Grafman, J |
| author_sort | Zamboni, G |
| collection | OXFORD |
| description | BACKGROUND: Aberrant social behavior is a defining symptom of frontotemporal dementia (FTD) and may eventually occur in all syndromes composing the FTD spectrum. Two main behavioral abnormalities have been described: apathy and disinhibition, but their neuroanatomical correlates remain underspecified. METHODS: Sixty-two patients with a clinical diagnosis of FTD participated in the study. Voxel-based morphometry of MRI data was performed to explore the association between gray matter loss and severity of the two behavioral profiles as measured by the Apathy and Disinhibition subscales of the Frontal Systems Behavior Scale. RESULTS: Compared with a group of controls, the FTD group showed extensive bilateral atrophy predominantly involving frontal and temporal lobes. Within the FTD group, the severity of apathy correlated with atrophy in the right dorsolateral prefrontal cortex. The severity of disinhibition correlated with atrophy in the right nucleus accumbens, right superior temporal sulcus, and right mediotemporal limbic structures. CONCLUSIONS: Prefrontal and temporal regions are differentially associated with apathy and disinhibition. Our results support the view that successful execution of complex social behaviors relies on the integration of social knowledge and executive functions, represented in the prefrontal cortex, and reward attribution and emotional processing, represented in mesolimbic structures. |
| first_indexed | 2024-03-06T19:03:25Z |
| format | Journal article |
| id | oxford-uuid:1452f3b5-bb72-45fd-a795-a3926e3de239 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:03:25Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:1452f3b5-bb72-45fd-a795-a3926e3de2392022-03-26T10:19:01ZApathy and disinhibition in frontotemporal dementia: Insights into their neural correlates.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1452f3b5-bb72-45fd-a795-a3926e3de239EnglishSymplectic Elements at Oxford2008Zamboni, GHuey, EKrueger, FNichelli, PGrafman, J BACKGROUND: Aberrant social behavior is a defining symptom of frontotemporal dementia (FTD) and may eventually occur in all syndromes composing the FTD spectrum. Two main behavioral abnormalities have been described: apathy and disinhibition, but their neuroanatomical correlates remain underspecified. METHODS: Sixty-two patients with a clinical diagnosis of FTD participated in the study. Voxel-based morphometry of MRI data was performed to explore the association between gray matter loss and severity of the two behavioral profiles as measured by the Apathy and Disinhibition subscales of the Frontal Systems Behavior Scale. RESULTS: Compared with a group of controls, the FTD group showed extensive bilateral atrophy predominantly involving frontal and temporal lobes. Within the FTD group, the severity of apathy correlated with atrophy in the right dorsolateral prefrontal cortex. The severity of disinhibition correlated with atrophy in the right nucleus accumbens, right superior temporal sulcus, and right mediotemporal limbic structures. CONCLUSIONS: Prefrontal and temporal regions are differentially associated with apathy and disinhibition. Our results support the view that successful execution of complex social behaviors relies on the integration of social knowledge and executive functions, represented in the prefrontal cortex, and reward attribution and emotional processing, represented in mesolimbic structures. |
| spellingShingle | Zamboni, G Huey, E Krueger, F Nichelli, P Grafman, J Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. |
| title | Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. |
| title_full | Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. |
| title_fullStr | Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. |
| title_full_unstemmed | Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. |
| title_short | Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. |
| title_sort | apathy and disinhibition in frontotemporal dementia insights into their neural correlates |
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