HIF hydroxylation and cellular oxygen sensing.
Hypoxia-inducible factor (HIF) is a transcriptional complex that mediates a broad range of cellular and systemic responses to hypoxia. Analysis of HIF-alpha subunits has demonstrated that its activity is regulated by a series of oxygen-dependent enzymatic hydroxylations at specific prolyl and aspara...
| Главные авторы: | , |
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| Формат: | Conference item |
| Опубликовано: |
2004
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