HIF hydroxylation and cellular oxygen sensing.
Hypoxia-inducible factor (HIF) is a transcriptional complex that mediates a broad range of cellular and systemic responses to hypoxia. Analysis of HIF-alpha subunits has demonstrated that its activity is regulated by a series of oxygen-dependent enzymatic hydroxylations at specific prolyl and aspara...
| Main Authors: | , |
|---|---|
| Format: | Conference item |
| Udgivet: |
2004
|