Direct and indirect electron transfer between electrodes and redox proteins.
The direct electrochemistry of redox proteins has been achieved at a variety of electrodes, including modified gold, pyrolytic graphite and metal oxides. Careful design of electrode surfaces and electrolyte conditions are required for the attainment of rapid and reversible protein-electrode interact...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1988
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| _version_ | 1797054894454079488 |
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| author | Frew, J Hill, H |
| author_facet | Frew, J Hill, H |
| author_sort | Frew, J |
| collection | OXFORD |
| description | The direct electrochemistry of redox proteins has been achieved at a variety of electrodes, including modified gold, pyrolytic graphite and metal oxides. Careful design of electrode surfaces and electrolyte conditions are required for the attainment of rapid and reversible protein-electrode interaction. The electron transfer reactions of more complex systems, such as redox enzymes, are now being examined. The 'well-behaved' electrochemistry of redox proteins can be usefully exploited by coupling the electrode reaction to enzymes for which the redox proteins act as cofactors. In systems where direct electron transfer is very slow, small electron carriers, or mediators, may be employed to enhance the rate of electron exchange with the electrode. The organometallic compound ferrocene and its derivatives have proved particularly effective in this role. A new generation of electrochemical biosensors employs ferrocene derivatives as mediators. |
| first_indexed | 2024-03-06T19:03:43Z |
| format | Journal article |
| id | oxford-uuid:1469d0df-ed63-415c-878e-f2b6b876ef73 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:03:43Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:1469d0df-ed63-415c-878e-f2b6b876ef732022-03-26T10:19:40ZDirect and indirect electron transfer between electrodes and redox proteins.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1469d0df-ed63-415c-878e-f2b6b876ef73EnglishSymplectic Elements at Oxford1988Frew, JHill, HThe direct electrochemistry of redox proteins has been achieved at a variety of electrodes, including modified gold, pyrolytic graphite and metal oxides. Careful design of electrode surfaces and electrolyte conditions are required for the attainment of rapid and reversible protein-electrode interaction. The electron transfer reactions of more complex systems, such as redox enzymes, are now being examined. The 'well-behaved' electrochemistry of redox proteins can be usefully exploited by coupling the electrode reaction to enzymes for which the redox proteins act as cofactors. In systems where direct electron transfer is very slow, small electron carriers, or mediators, may be employed to enhance the rate of electron exchange with the electrode. The organometallic compound ferrocene and its derivatives have proved particularly effective in this role. A new generation of electrochemical biosensors employs ferrocene derivatives as mediators. |
| spellingShingle | Frew, J Hill, H Direct and indirect electron transfer between electrodes and redox proteins. |
| title | Direct and indirect electron transfer between electrodes and redox proteins. |
| title_full | Direct and indirect electron transfer between electrodes and redox proteins. |
| title_fullStr | Direct and indirect electron transfer between electrodes and redox proteins. |
| title_full_unstemmed | Direct and indirect electron transfer between electrodes and redox proteins. |
| title_short | Direct and indirect electron transfer between electrodes and redox proteins. |
| title_sort | direct and indirect electron transfer between electrodes and redox proteins |
| work_keys_str_mv | AT frewj directandindirectelectrontransferbetweenelectrodesandredoxproteins AT hillh directandindirectelectrontransferbetweenelectrodesandredoxproteins |