Expression of HIF-1a, HIF-2a (EPAS1), and their target genes in paraganglioma and phaeochromocytoma with VHL and SDH mutations

Podobne zapisy

• Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations.
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• Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B (SDH-B) gene mutation carriers.
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• Effects of point mutations in pVHL on the binding of HIF-1α.
  od: Domene, C, i wsp.
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• Effects of point mutations in pVHL on the binding of HIF-1α
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• Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.
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