Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways.
Both tumor hypoxia and dysregulated metabolism are classical features of cancer. Recent analyses have revealed complex interconnections between oncogenic activation, hypoxia signaling systems and metabolic pathways that are dysregulated in cancer. These studies have demonstrated that rather than res...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2014
|
| _version_ | 1797054909744414720 |
|---|---|
| author | Masson, N Ratcliffe, P |
| author_facet | Masson, N Ratcliffe, P |
| author_sort | Masson, N |
| collection | OXFORD |
| description | Both tumor hypoxia and dysregulated metabolism are classical features of cancer. Recent analyses have revealed complex interconnections between oncogenic activation, hypoxia signaling systems and metabolic pathways that are dysregulated in cancer. These studies have demonstrated that rather than responding simply to error signals arising from energy depletion or tumor hypoxia, metabolic and hypoxia signaling pathways are also directly connected to oncogenic signaling mechanisms at many points. This review will summarize current understanding of the role of hypoxia inducible factor (HIF) in these networks. It will also discuss the role of these interconnected pathways in generating the cancer phenotype; in particular, the implications of switching massive pathways that are physiologically 'hard-wired' to oncogenic mechanisms driving cancer. |
| first_indexed | 2024-03-06T19:03:57Z |
| format | Journal article |
| id | oxford-uuid:147ca1a0-bea4-4818-86f9-69fdd5fd08f4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:03:57Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:147ca1a0-bea4-4818-86f9-69fdd5fd08f42022-03-26T10:20:04ZHypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:147ca1a0-bea4-4818-86f9-69fdd5fd08f4EnglishSymplectic Elements at Oxford2014Masson, NRatcliffe, PBoth tumor hypoxia and dysregulated metabolism are classical features of cancer. Recent analyses have revealed complex interconnections between oncogenic activation, hypoxia signaling systems and metabolic pathways that are dysregulated in cancer. These studies have demonstrated that rather than responding simply to error signals arising from energy depletion or tumor hypoxia, metabolic and hypoxia signaling pathways are also directly connected to oncogenic signaling mechanisms at many points. This review will summarize current understanding of the role of hypoxia inducible factor (HIF) in these networks. It will also discuss the role of these interconnected pathways in generating the cancer phenotype; in particular, the implications of switching massive pathways that are physiologically 'hard-wired' to oncogenic mechanisms driving cancer. |
| spellingShingle | Masson, N Ratcliffe, P Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. |
| title | Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. |
| title_full | Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. |
| title_fullStr | Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. |
| title_full_unstemmed | Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. |
| title_short | Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. |
| title_sort | hypoxia signaling pathways in cancer metabolism the importance of co selecting interconnected physiological pathways |
| work_keys_str_mv | AT massonn hypoxiasignalingpathwaysincancermetabolismtheimportanceofcoselectinginterconnectedphysiologicalpathways AT ratcliffep hypoxiasignalingpathwaysincancermetabolismtheimportanceofcoselectinginterconnectedphysiologicalpathways |