A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos.
We conducted a randomized open trial of oral chloramphenicol (50mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range)...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1797054935545675776 |
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| author | Phongmany, S Phetsouvanh, R Sisouphone, S Darasavath, C Vongphachane, P Rattanavong, O Mayxay, M Ramsay, A Blacksell, S Thammavong, C Syhavong, B White, N Newton, P |
| author_facet | Phongmany, S Phetsouvanh, R Sisouphone, S Darasavath, C Vongphachane, P Rattanavong, O Mayxay, M Ramsay, A Blacksell, S Thammavong, C Syhavong, B White, N Newton, P |
| author_sort | Phongmany, S |
| collection | OXFORD |
| description | We conducted a randomized open trial of oral chloramphenicol (50mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P<0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost. |
| first_indexed | 2024-03-06T19:04:19Z |
| format | Journal article |
| id | oxford-uuid:149e33a0-d56d-479c-9e45-85dd8405f3c4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:04:19Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:149e33a0-d56d-479c-9e45-85dd8405f3c42022-03-26T10:20:45ZA randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:149e33a0-d56d-479c-9e45-85dd8405f3c4EnglishSymplectic Elements at Oxford2005Phongmany, SPhetsouvanh, RSisouphone, SDarasavath, CVongphachane, PRattanavong, OMayxay, MRamsay, ABlacksell, SThammavong, CSyhavong, BWhite, NNewton, PWe conducted a randomized open trial of oral chloramphenicol (50mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P<0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost. |
| spellingShingle | Phongmany, S Phetsouvanh, R Sisouphone, S Darasavath, C Vongphachane, P Rattanavong, O Mayxay, M Ramsay, A Blacksell, S Thammavong, C Syhavong, B White, N Newton, P A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos. |
| title | A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos. |
| title_full | A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos. |
| title_fullStr | A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos. |
| title_full_unstemmed | A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos. |
| title_short | A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos. |
| title_sort | randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in laos |
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