R-loops induce repressive chromatin marks over mammalian gene terminators.
The formation of R-loops is a natural consequence of the transcription process, caused by invasion of the DNA duplex by nascent transcripts. These structures have been considered rare transcriptional by-products with potentially harmful effects on genome integrity owing to the fragility of the displ...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Publishing Group
2014
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