Fully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging

Fully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging

Introduction Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of l-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor tissues by blocking locally T-lymphocyte proliferation. Recently, 1-(2-[19F]fluoroethyl)-dl-trypt...

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Bibliographic Details
Main Authors: Henrottin, J, Lemaire, C, Egrise, D, Zervosen, A, Van Den Eynde, B, Plenevaux, A, Franci, X, Goldman, S, Luxen, A
Format: Journal article
Language:English
Published: Elsevier 2016

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