Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.

PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellula...

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Main Authors: Wales, J, Andreakos, E, Feldmann, M, Foxwell, B
格式: Journal article
语言:English
出版: 2007