Tracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responses.
There are few studies that have examined the frequencies of epitope-specific CD4(+) T cells following the use of a highly effective vaccine, yet such data would potentially be of value for the development of novel vaccination strategies. In this study we tracked human epitope-specific CD4(+) T cell...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1826260393675194368 |
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| author | Jones, L Malavige, G Jeffery, K Kemp, E Breuer, J Klenerman, P Ogg, G |
| author_facet | Jones, L Malavige, G Jeffery, K Kemp, E Breuer, J Klenerman, P Ogg, G |
| author_sort | Jones, L |
| collection | OXFORD |
| description | There are few studies that have examined the frequencies of epitope-specific CD4(+) T cells following the use of a highly effective vaccine, yet such data would potentially be of value for the development of novel vaccination strategies. In this study we tracked human epitope-specific CD4(+) T cell responses over time after immunisation with a live attenuated varicella zoster virus vaccine by MHC Class II tetrameric complexes and functional assays. We show that the peptide-specific responses reflect those against whole virus antigens, and are similar in both frequency and phenotype to those found in healthy volunteers, despite a highly attenuated and clinically inapparent infection. |
| first_indexed | 2024-03-06T19:04:56Z |
| format | Journal article |
| id | oxford-uuid:14ce83d8-032b-41dc-b461-78bc662610cd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:04:56Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:14ce83d8-032b-41dc-b461-78bc662610cd2022-03-26T10:21:56ZTracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responses.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:14ce83d8-032b-41dc-b461-78bc662610cdEnglishSymplectic Elements at Oxford2009Jones, LMalavige, GJeffery, KKemp, EBreuer, JKlenerman, POgg, GThere are few studies that have examined the frequencies of epitope-specific CD4(+) T cells following the use of a highly effective vaccine, yet such data would potentially be of value for the development of novel vaccination strategies. In this study we tracked human epitope-specific CD4(+) T cell responses over time after immunisation with a live attenuated varicella zoster virus vaccine by MHC Class II tetrameric complexes and functional assays. We show that the peptide-specific responses reflect those against whole virus antigens, and are similar in both frequency and phenotype to those found in healthy volunteers, despite a highly attenuated and clinically inapparent infection. |
| spellingShingle | Jones, L Malavige, G Jeffery, K Kemp, E Breuer, J Klenerman, P Ogg, G Tracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responses. |
| title | Tracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responses. |
| title_full | Tracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responses. |
| title_fullStr | Tracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responses. |
| title_full_unstemmed | Tracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responses. |
| title_short | Tracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responses. |
| title_sort | tracking epitope specific antiviral cd4 t cell responses to a live attenuated vaccine reveals ongoing functional responses |
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