GluR-A-dependent synaptic plasticity is required for the temporal encoding of nonspatial information.
Four related experiments studied operant performance of mice on differential reinforcement of low rates of responding (DRL) paradigms. Experiment 1 showed that excitotoxic hippocampal lesions impaired performance of a 10-s DRL schedule (DRL-10). Experiments 2 and 3 showed that GluR-A AMPA receptor s...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1826260398596161536 |
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| author | Reisel, D Bannerman, D Deacon, R Sprengel, R Seeburg, P Rawlins, J |
| author_facet | Reisel, D Bannerman, D Deacon, R Sprengel, R Seeburg, P Rawlins, J |
| author_sort | Reisel, D |
| collection | OXFORD |
| description | Four related experiments studied operant performance of mice on differential reinforcement of low rates of responding (DRL) paradigms. Experiment 1 showed that excitotoxic hippocampal lesions impaired performance of a 10-s DRL schedule (DRL-10). Experiments 2 and 3 showed that GluR-A AMPA receptor subunit knockout mice, which are deficient in CA3-CA1 long-term potentiation (LTP), were markedly impaired at 15 s (DRL-15), but less impaired at DRL-10. Experiment 4 compared DRL-15 performance in mice from the 2 strains from which the GluR-A colony was derived and showed that they did not differ. The results show that GluR-A-containing AMPA receptors are required for normal performance on hippocampus-dependent, nonspatial working memory tasks, consistent with a role for GluR-A in the temporal encoding (what happened when) of nonspatial information. |
| first_indexed | 2024-03-06T19:05:00Z |
| format | Journal article |
| id | oxford-uuid:14d36cc0-8c3e-4841-911a-3657d4eac76e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:05:00Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:14d36cc0-8c3e-4841-911a-3657d4eac76e2022-03-26T10:22:00ZGluR-A-dependent synaptic plasticity is required for the temporal encoding of nonspatial information.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:14d36cc0-8c3e-4841-911a-3657d4eac76eEnglishSymplectic Elements at Oxford2005Reisel, DBannerman, DDeacon, RSprengel, RSeeburg, PRawlins, JFour related experiments studied operant performance of mice on differential reinforcement of low rates of responding (DRL) paradigms. Experiment 1 showed that excitotoxic hippocampal lesions impaired performance of a 10-s DRL schedule (DRL-10). Experiments 2 and 3 showed that GluR-A AMPA receptor subunit knockout mice, which are deficient in CA3-CA1 long-term potentiation (LTP), were markedly impaired at 15 s (DRL-15), but less impaired at DRL-10. Experiment 4 compared DRL-15 performance in mice from the 2 strains from which the GluR-A colony was derived and showed that they did not differ. The results show that GluR-A-containing AMPA receptors are required for normal performance on hippocampus-dependent, nonspatial working memory tasks, consistent with a role for GluR-A in the temporal encoding (what happened when) of nonspatial information. |
| spellingShingle | Reisel, D Bannerman, D Deacon, R Sprengel, R Seeburg, P Rawlins, J GluR-A-dependent synaptic plasticity is required for the temporal encoding of nonspatial information. |
| title | GluR-A-dependent synaptic plasticity is required for the temporal encoding of nonspatial information. |
| title_full | GluR-A-dependent synaptic plasticity is required for the temporal encoding of nonspatial information. |
| title_fullStr | GluR-A-dependent synaptic plasticity is required for the temporal encoding of nonspatial information. |
| title_full_unstemmed | GluR-A-dependent synaptic plasticity is required for the temporal encoding of nonspatial information. |
| title_short | GluR-A-dependent synaptic plasticity is required for the temporal encoding of nonspatial information. |
| title_sort | glur a dependent synaptic plasticity is required for the temporal encoding of nonspatial information |
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