Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India.
In a study of mainly paucibacillary leprosy-affected sib-pair families from South India, in addition to the expected associations with the HLA-DRB1 locus, we have identified significant association with a functional variant of the MICA gene as well as a microsatellite in the flanking region of the M...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797054986773856256 |
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| author | Tosh, K Ravikumar, M Bell, J Meisner, S Hill, A Pitchappan, R |
| author_facet | Tosh, K Ravikumar, M Bell, J Meisner, S Hill, A Pitchappan, R |
| author_sort | Tosh, K |
| collection | OXFORD |
| description | In a study of mainly paucibacillary leprosy-affected sib-pair families from South India, in addition to the expected associations with the HLA-DRB1 locus, we have identified significant association with a functional variant of the MICA gene as well as a microsatellite in the flanking region of the MICB gene. The associations with MICA and MICB cannot be accounted for by linkage disequilibrium with the HLA class II locus indicating a role in genetic susceptibility to leprosy that is independent of HLA-DRB1. Previous studies have shown that MICA and MICB are expressed on the surface of cells in response to infection, where they are recognized by the NKG2D receptor on gammadelta T cells, CD8+ alphabeta T cells and natural killer cells, all of which contribute to defense against mycobacteria. The MICA*5A5.1 allele, associated here with leprosy susceptibility, encodes a protein lacking a cytoplasmic tail providing a possible mechanism for defective immune surveillance against mycobacteria. |
| first_indexed | 2024-03-06T19:05:04Z |
| format | Journal article |
| id | oxford-uuid:14d79485-95f6-40e8-86a7-3416e41288e1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:05:04Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:14d79485-95f6-40e8-86a7-3416e41288e12022-03-26T10:22:09ZVariation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:14d79485-95f6-40e8-86a7-3416e41288e1EnglishSymplectic Elements at Oxford2006Tosh, KRavikumar, MBell, JMeisner, SHill, APitchappan, RIn a study of mainly paucibacillary leprosy-affected sib-pair families from South India, in addition to the expected associations with the HLA-DRB1 locus, we have identified significant association with a functional variant of the MICA gene as well as a microsatellite in the flanking region of the MICB gene. The associations with MICA and MICB cannot be accounted for by linkage disequilibrium with the HLA class II locus indicating a role in genetic susceptibility to leprosy that is independent of HLA-DRB1. Previous studies have shown that MICA and MICB are expressed on the surface of cells in response to infection, where they are recognized by the NKG2D receptor on gammadelta T cells, CD8+ alphabeta T cells and natural killer cells, all of which contribute to defense against mycobacteria. The MICA*5A5.1 allele, associated here with leprosy susceptibility, encodes a protein lacking a cytoplasmic tail providing a possible mechanism for defective immune surveillance against mycobacteria. |
| spellingShingle | Tosh, K Ravikumar, M Bell, J Meisner, S Hill, A Pitchappan, R Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India. |
| title | Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India. |
| title_full | Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India. |
| title_fullStr | Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India. |
| title_full_unstemmed | Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India. |
| title_short | Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India. |
| title_sort | variation in mica and micb genes and enhanced susceptibility to paucibacillary leprosy in south india |
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