Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol...
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| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
Springer Nature
2014
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| _version_ | 1826260417055293440 |
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| author | Postmus, I Trompet, S Deshmukh, H Barnes, MR Li, X Warren, H Chasman, D Zhou, K Arsenault, B Donnelly, L Wiggins, K Avery, C Griffin, P Feng, Q Taylor, K Li, G Evans, D Smith, A De Keyser, C Johnson, A De Craen, A Stott, D Buckley, B Ford, I Westendorp, R Slagboom, P Sattar, N Munroe, P Sever, P Poulter, N Stanton, A Shields, D O'Brien, E Shaw-Hawkins, S Chen, Y Nickerson, D Smith, J Dubé, M Boekholdt, S Hovingh, G Kastelein, J McKeigue, P Betteridge, J Neil, A Durrington, P Doney, A Carr, F Morris, A McCarthy, M Groop, L Ahlqvist, E Bis, J Rice, K Smith, N Lumley, T Whitsel, E Stürmer, T Boerwinkle, E Ngwa, J O'Donnell, C Vasan, R Wei, W Wilke, R Liu, C Sun, F Guo, X Heckbert, SR Post, W Sotoodehnia, N Arnold, A Stafford, J Ding, J Herrington, D Kritchevsky, S Eiriksdottir, G Launer, L Harris, T Chu, A Giulianini, F Macfadyen, J Barratt, B Nyberg, F Stricker, B Uitterlinden, A Hofman, A Rivadeneira, F Emilsson, V Franco, O Ridker, P Gudnason, V Liu, Y Denny, J Ballantyne, C Rotter, J Adrienne Cupples, L Psaty, B Palmer, C Tardif, J Colhoun, H Hitman, G Krauss, R Wouter Jukema, J Caulfield, M Wellcome Trust Case Control Consortium |
| author_facet | Postmus, I Trompet, S Deshmukh, H Barnes, MR Li, X Warren, H Chasman, D Zhou, K Arsenault, B Donnelly, L Wiggins, K Avery, C Griffin, P Feng, Q Taylor, K Li, G Evans, D Smith, A De Keyser, C Johnson, A De Craen, A Stott, D Buckley, B Ford, I Westendorp, R Slagboom, P Sattar, N Munroe, P Sever, P Poulter, N Stanton, A Shields, D O'Brien, E Shaw-Hawkins, S Chen, Y Nickerson, D Smith, J Dubé, M Boekholdt, S Hovingh, G Kastelein, J McKeigue, P Betteridge, J Neil, A Durrington, P Doney, A Carr, F Morris, A McCarthy, M Groop, L Ahlqvist, E Bis, J Rice, K Smith, N Lumley, T Whitsel, E Stürmer, T Boerwinkle, E Ngwa, J O'Donnell, C Vasan, R Wei, W Wilke, R Liu, C Sun, F Guo, X Heckbert, SR Post, W Sotoodehnia, N Arnold, A Stafford, J Ding, J Herrington, D Kritchevsky, S Eiriksdottir, G Launer, L Harris, T Chu, A Giulianini, F Macfadyen, J Barratt, B Nyberg, F Stricker, B Uitterlinden, A Hofman, A Rivadeneira, F Emilsson, V Franco, O Ridker, P Gudnason, V Liu, Y Denny, J Ballantyne, C Rotter, J Adrienne Cupples, L Psaty, B Palmer, C Tardif, J Colhoun, H Hitman, G Krauss, R Wouter Jukema, J Caulfield, M Wellcome Trust Case Control Consortium |
| author_sort | Postmus, I |
| collection | OXFORD |
| description | Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response. |
| first_indexed | 2024-03-06T19:05:18Z |
| format | Journal article |
| id | oxford-uuid:14ecb29a-a3ff-4376-a16b-9e07e0d2ca6b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:05:18Z |
| publishDate | 2014 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:14ecb29a-a3ff-4376-a16b-9e07e0d2ca6b2022-03-26T10:22:45ZPharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statinsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:14ecb29a-a3ff-4376-a16b-9e07e0d2ca6bEnglishSymplectic Elements at OxfordSpringer Nature2014Postmus, ITrompet, SDeshmukh, HBarnes, MRLi, XWarren, HChasman, DZhou, KArsenault, BDonnelly, LWiggins, KAvery, CGriffin, PFeng, QTaylor, KLi, GEvans, DSmith, ADe Keyser, CJohnson, ADe Craen, AStott, DBuckley, BFord, IWestendorp, RSlagboom, PSattar, NMunroe, PSever, PPoulter, NStanton, AShields, DO'Brien, EShaw-Hawkins, SChen, YNickerson, DSmith, JDubé, MBoekholdt, SHovingh, GKastelein, JMcKeigue, PBetteridge, JNeil, ADurrington, PDoney, ACarr, FMorris, AMcCarthy, MGroop, LAhlqvist, EBis, JRice, KSmith, NLumley, TWhitsel, EStürmer, TBoerwinkle, ENgwa, JO'Donnell, CVasan, RWei, WWilke, RLiu, CSun, FGuo, XHeckbert, SRPost, WSotoodehnia, NArnold, AStafford, JDing, JHerrington, DKritchevsky, SEiriksdottir, GLauner, LHarris, TChu, AGiulianini, FMacfadyen, JBarratt, BNyberg, FStricker, BUitterlinden, AHofman, ARivadeneira, FEmilsson, VFranco, ORidker, PGudnason, VLiu, YDenny, JBallantyne, CRotter, JAdrienne Cupples, LPsaty, BPalmer, CTardif, JColhoun, HHitman, GKrauss, RWouter Jukema, JCaulfield, MWellcome Trust Case Control ConsortiumStatins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response. |
| spellingShingle | Postmus, I Trompet, S Deshmukh, H Barnes, MR Li, X Warren, H Chasman, D Zhou, K Arsenault, B Donnelly, L Wiggins, K Avery, C Griffin, P Feng, Q Taylor, K Li, G Evans, D Smith, A De Keyser, C Johnson, A De Craen, A Stott, D Buckley, B Ford, I Westendorp, R Slagboom, P Sattar, N Munroe, P Sever, P Poulter, N Stanton, A Shields, D O'Brien, E Shaw-Hawkins, S Chen, Y Nickerson, D Smith, J Dubé, M Boekholdt, S Hovingh, G Kastelein, J McKeigue, P Betteridge, J Neil, A Durrington, P Doney, A Carr, F Morris, A McCarthy, M Groop, L Ahlqvist, E Bis, J Rice, K Smith, N Lumley, T Whitsel, E Stürmer, T Boerwinkle, E Ngwa, J O'Donnell, C Vasan, R Wei, W Wilke, R Liu, C Sun, F Guo, X Heckbert, SR Post, W Sotoodehnia, N Arnold, A Stafford, J Ding, J Herrington, D Kritchevsky, S Eiriksdottir, G Launer, L Harris, T Chu, A Giulianini, F Macfadyen, J Barratt, B Nyberg, F Stricker, B Uitterlinden, A Hofman, A Rivadeneira, F Emilsson, V Franco, O Ridker, P Gudnason, V Liu, Y Denny, J Ballantyne, C Rotter, J Adrienne Cupples, L Psaty, B Palmer, C Tardif, J Colhoun, H Hitman, G Krauss, R Wouter Jukema, J Caulfield, M Wellcome Trust Case Control Consortium Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title_full | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title_fullStr | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title_full_unstemmed | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title_short | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title_sort | pharmacogenetic meta analysis of genome wide association studies of ldl cholesterol response to statins |
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