Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol...

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প্রধান লেখক: Postmus, I, Trompet, S, Deshmukh, H, Barnes, MR, Li, X, Warren, H, Chasman, D, Zhou, K, Arsenault, B, Donnelly, L, Wiggins, K, Avery, C, Griffin, P, Feng, Q, Taylor, K, Li, G, Evans, D, Smith, A, De Keyser, C, Johnson, A, De Craen, A, Stott, D, Buckley, B, Ford, I, Westendorp, R, Slagboom, P, Sattar, N, Munroe, P, Sever, P, Poulter, N, Stanton, A, Shields, D, O'Brien, E, Shaw-Hawkins, S, Chen, Y, Nickerson, D, Smith, J, Dubé, M, Boekholdt, S, Hovingh, G, Kastelein, J, McKeigue, P, Betteridge, J, Neil, A, Durrington, P, Doney, A, Carr, F, Morris, A, McCarthy, M, Groop, L, Ahlqvist, E, Bis, J, Rice, K, Smith, N, Lumley, T, Whitsel, E, Stürmer, T, Boerwinkle, E, Ngwa, J, O'Donnell, C, Vasan, R, Wei, W, Wilke, R, Liu, C, Sun, F, Guo, X, Heckbert, SR, Post, W, Sotoodehnia, N, Arnold, A, Stafford, J, Ding, J, Herrington, D, Kritchevsky, S, Eiriksdottir, G, Launer, L, Harris, T, Chu, A, Giulianini, F, Macfadyen, J, Barratt, B, Nyberg, F, Stricker, B, Uitterlinden, A, Hofman, A, Rivadeneira, F, Emilsson, V, Franco, O, Ridker, P, Gudnason, V, Liu, Y, Denny, J, Ballantyne, C, Rotter, J, Adrienne Cupples, L, Psaty, B, Palmer, C, Tardif, J, Colhoun, H, Hitman, G, Krauss, R, Wouter Jukema, J, Caulfield, M, Wellcome Trust Case Control Consortium
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: Springer Nature 2014
_version_ 1826260417055293440
author Postmus, I
Trompet, S
Deshmukh, H
Barnes, MR
Li, X
Warren, H
Chasman, D
Zhou, K
Arsenault, B
Donnelly, L
Wiggins, K
Avery, C
Griffin, P
Feng, Q
Taylor, K
Li, G
Evans, D
Smith, A
De Keyser, C
Johnson, A
De Craen, A
Stott, D
Buckley, B
Ford, I
Westendorp, R
Slagboom, P
Sattar, N
Munroe, P
Sever, P
Poulter, N
Stanton, A
Shields, D
O'Brien, E
Shaw-Hawkins, S
Chen, Y
Nickerson, D
Smith, J
Dubé, M
Boekholdt, S
Hovingh, G
Kastelein, J
McKeigue, P
Betteridge, J
Neil, A
Durrington, P
Doney, A
Carr, F
Morris, A
McCarthy, M
Groop, L
Ahlqvist, E
Bis, J
Rice, K
Smith, N
Lumley, T
Whitsel, E
Stürmer, T
Boerwinkle, E
Ngwa, J
O'Donnell, C
Vasan, R
Wei, W
Wilke, R
Liu, C
Sun, F
Guo, X
Heckbert, SR
Post, W
Sotoodehnia, N
Arnold, A
Stafford, J
Ding, J
Herrington, D
Kritchevsky, S
Eiriksdottir, G
Launer, L
Harris, T
Chu, A
Giulianini, F
Macfadyen, J
Barratt, B
Nyberg, F
Stricker, B
Uitterlinden, A
Hofman, A
Rivadeneira, F
Emilsson, V
Franco, O
Ridker, P
Gudnason, V
Liu, Y
Denny, J
Ballantyne, C
Rotter, J
Adrienne Cupples, L
Psaty, B
Palmer, C
Tardif, J
Colhoun, H
Hitman, G
Krauss, R
Wouter Jukema, J
Caulfield, M
Wellcome Trust Case Control Consortium
author_facet Postmus, I
Trompet, S
Deshmukh, H
Barnes, MR
Li, X
Warren, H
Chasman, D
Zhou, K
Arsenault, B
Donnelly, L
Wiggins, K
Avery, C
Griffin, P
Feng, Q
Taylor, K
Li, G
Evans, D
Smith, A
De Keyser, C
Johnson, A
De Craen, A
Stott, D
Buckley, B
Ford, I
Westendorp, R
Slagboom, P
Sattar, N
Munroe, P
Sever, P
Poulter, N
Stanton, A
Shields, D
O'Brien, E
Shaw-Hawkins, S
Chen, Y
Nickerson, D
Smith, J
Dubé, M
Boekholdt, S
Hovingh, G
Kastelein, J
McKeigue, P
Betteridge, J
Neil, A
Durrington, P
Doney, A
Carr, F
Morris, A
McCarthy, M
Groop, L
Ahlqvist, E
Bis, J
Rice, K
Smith, N
Lumley, T
Whitsel, E
Stürmer, T
Boerwinkle, E
Ngwa, J
O'Donnell, C
Vasan, R
Wei, W
Wilke, R
Liu, C
Sun, F
Guo, X
Heckbert, SR
Post, W
Sotoodehnia, N
Arnold, A
Stafford, J
Ding, J
Herrington, D
Kritchevsky, S
Eiriksdottir, G
Launer, L
Harris, T
Chu, A
Giulianini, F
Macfadyen, J
Barratt, B
Nyberg, F
Stricker, B
Uitterlinden, A
Hofman, A
Rivadeneira, F
Emilsson, V
Franco, O
Ridker, P
Gudnason, V
Liu, Y
Denny, J
Ballantyne, C
Rotter, J
Adrienne Cupples, L
Psaty, B
Palmer, C
Tardif, J
Colhoun, H
Hitman, G
Krauss, R
Wouter Jukema, J
Caulfield, M
Wellcome Trust Case Control Consortium
author_sort Postmus, I
collection OXFORD
description Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.
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spelling oxford-uuid:14ecb29a-a3ff-4376-a16b-9e07e0d2ca6b2022-03-26T10:22:45ZPharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statinsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:14ecb29a-a3ff-4376-a16b-9e07e0d2ca6bEnglishSymplectic Elements at OxfordSpringer Nature2014Postmus, ITrompet, SDeshmukh, HBarnes, MRLi, XWarren, HChasman, DZhou, KArsenault, BDonnelly, LWiggins, KAvery, CGriffin, PFeng, QTaylor, KLi, GEvans, DSmith, ADe Keyser, CJohnson, ADe Craen, AStott, DBuckley, BFord, IWestendorp, RSlagboom, PSattar, NMunroe, PSever, PPoulter, NStanton, AShields, DO'Brien, EShaw-Hawkins, SChen, YNickerson, DSmith, JDubé, MBoekholdt, SHovingh, GKastelein, JMcKeigue, PBetteridge, JNeil, ADurrington, PDoney, ACarr, FMorris, AMcCarthy, MGroop, LAhlqvist, EBis, JRice, KSmith, NLumley, TWhitsel, EStürmer, TBoerwinkle, ENgwa, JO'Donnell, CVasan, RWei, WWilke, RLiu, CSun, FGuo, XHeckbert, SRPost, WSotoodehnia, NArnold, AStafford, JDing, JHerrington, DKritchevsky, SEiriksdottir, GLauner, LHarris, TChu, AGiulianini, FMacfadyen, JBarratt, BNyberg, FStricker, BUitterlinden, AHofman, ARivadeneira, FEmilsson, VFranco, ORidker, PGudnason, VLiu, YDenny, JBallantyne, CRotter, JAdrienne Cupples, LPsaty, BPalmer, CTardif, JColhoun, HHitman, GKrauss, RWouter Jukema, JCaulfield, MWellcome Trust Case Control ConsortiumStatins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.
spellingShingle Postmus, I
Trompet, S
Deshmukh, H
Barnes, MR
Li, X
Warren, H
Chasman, D
Zhou, K
Arsenault, B
Donnelly, L
Wiggins, K
Avery, C
Griffin, P
Feng, Q
Taylor, K
Li, G
Evans, D
Smith, A
De Keyser, C
Johnson, A
De Craen, A
Stott, D
Buckley, B
Ford, I
Westendorp, R
Slagboom, P
Sattar, N
Munroe, P
Sever, P
Poulter, N
Stanton, A
Shields, D
O'Brien, E
Shaw-Hawkins, S
Chen, Y
Nickerson, D
Smith, J
Dubé, M
Boekholdt, S
Hovingh, G
Kastelein, J
McKeigue, P
Betteridge, J
Neil, A
Durrington, P
Doney, A
Carr, F
Morris, A
McCarthy, M
Groop, L
Ahlqvist, E
Bis, J
Rice, K
Smith, N
Lumley, T
Whitsel, E
Stürmer, T
Boerwinkle, E
Ngwa, J
O'Donnell, C
Vasan, R
Wei, W
Wilke, R
Liu, C
Sun, F
Guo, X
Heckbert, SR
Post, W
Sotoodehnia, N
Arnold, A
Stafford, J
Ding, J
Herrington, D
Kritchevsky, S
Eiriksdottir, G
Launer, L
Harris, T
Chu, A
Giulianini, F
Macfadyen, J
Barratt, B
Nyberg, F
Stricker, B
Uitterlinden, A
Hofman, A
Rivadeneira, F
Emilsson, V
Franco, O
Ridker, P
Gudnason, V
Liu, Y
Denny, J
Ballantyne, C
Rotter, J
Adrienne Cupples, L
Psaty, B
Palmer, C
Tardif, J
Colhoun, H
Hitman, G
Krauss, R
Wouter Jukema, J
Caulfield, M
Wellcome Trust Case Control Consortium
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
title Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
title_full Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
title_fullStr Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
title_full_unstemmed Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
title_short Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
title_sort pharmacogenetic meta analysis of genome wide association studies of ldl cholesterol response to statins
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