Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol...

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المؤلفون الرئيسيون: Postmus, I, Trompet, S, Deshmukh, H, Barnes, MR, Li, X, Warren, H, Chasman, D, Zhou, K, Arsenault, B, Donnelly, L, Wiggins, K, Avery, C, Griffin, P, Feng, Q, Taylor, K, Li, G, Evans, D, Smith, A, De Keyser, C, Johnson, A, De Craen, A, Stott, D, Buckley, B, Ford, I, Westendorp, R, Slagboom, P, Sattar, N, Munroe, P, Sever, P, Poulter, N, Stanton, A, Shields, D, O'Brien, E, Shaw-Hawkins, S, Chen, Y, Nickerson, D, Smith, J, Dubé, M, Boekholdt, S, Hovingh, G, Kastelein, J, McKeigue, P, Betteridge, J, Neil, A, Durrington, P, Doney, A, Carr, F, Morris, A, McCarthy, M, Groop, L, Ahlqvist, E, Bis, J, Rice, K, Smith, N, Lumley, T, Whitsel, E, Stürmer, T, Boerwinkle, E, Ngwa, J, O'Donnell, C, Vasan, R, Wei, W, Wilke, R, Liu, C, Sun, F, Guo, X, Heckbert, SR, Post, W, Sotoodehnia, N, Arnold, A, Stafford, J, Ding, J, Herrington, D, Kritchevsky, S, Eiriksdottir, G, Launer, L, Harris, T, Chu, A, Giulianini, F, Macfadyen, J, Barratt, B, Nyberg, F, Stricker, B, Uitterlinden, A, Hofman, A, Rivadeneira, F, Emilsson, V, Franco, O, Ridker, P, Gudnason, V, Liu, Y, Denny, J, Ballantyne, C, Rotter, J, Adrienne Cupples, L, Psaty, B, Palmer, C, Tardif, J, Colhoun, H, Hitman, G, Krauss, R, Wouter Jukema, J, Caulfield, M, Wellcome Trust Case Control Consortium
التنسيق: Journal article
اللغة:English
منشور في: Springer Nature 2014

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