High avidity antigen-specific CTL identified by CD8-independent tetramer staining.

High avidity antigen-specific CTL identified by CD8-independent tetramer staining.

Tetrameric MHC/peptide complexes are important tools for enumerating, phenotyping, and rapidly cloning Ag-specific T cells. It remains however unclear whether they can reliably distinguish between high and low avidity T cell clones. In this report, tetramers with mutated CD8 binding site selectively...

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Main Authors: Choi, E, Chen, J, Wooldridge, L, Salio, M, Lissina, A, Lissin, N, Hermans, I, Silk, J, Mirza, F, Palmowski, M, Dunbar, P, Jakobsen, B, Sewell, A, Cerundolo, V
Formato: Journal article
Idioma:English
Publicado: 2003

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