JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.
JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in vitro. Therefore, it has been argued that, depend...
Հիմնական հեղինակներ: | Adighibe, O, Turley, H, Leek, R, Harris, A, Coutts, A, La Thangue, N, Gatter, K, Pezzella, F |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
Springer Verlag
2014
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Նմանատիպ նյութեր
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p53-cofactor JMY is a multifunctional actin nucleation factor.
: Zuchero, J, և այլն
Հրապարակվել է: (2009) -
Mdm2 targets the p53 transcription cofactor JMY for degradation.
: Coutts, A, և այլն
Հրապարակվել է: (2007) -
Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α.
: Coutts, A, և այլն
Հրապարակվել է: (2011) -
Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α
: Coutts, A, և այլն
Հրապարակվել է: (2011) -
JMY functions as actin nucleation-promoting factor and mediator for p53-mediated DNA damage in porcine oocytes.
: Zili Lin, և այլն
Հրապարակվել է: (2014-01-01)