JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.
JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in vitro. Therefore, it has been argued that, depend...
Váldodahkkit: | Adighibe, O, Turley, H, Leek, R, Harris, A, Coutts, A, La Thangue, N, Gatter, K, Pezzella, F |
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Materiálatiipa: | Journal article |
Giella: | English |
Almmustuhtton: |
Springer Verlag
2014
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Geahča maid
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p53-cofactor JMY is a multifunctional actin nucleation factor.
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Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α.
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Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α
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Almmustuhtton: (2011) -
JMY functions as actin nucleation-promoting factor and mediator for p53-mediated DNA damage in porcine oocytes.
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