JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.

JMY protein, a regulator of P53 and cytoplasmic actin filaments, is expressed in normal and neoplastic tissues.

JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to DNA damage, while by promoting actin filament assembly in the cytoplasm; it induces cell motility in vitro. Therefore, it has been argued that, depend...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Adighibe, O, Turley, H, Leek, R, Harris, A, Coutts, A, La Thangue, N, Gatter, K, Pezzella, F
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Springer Verlag 2014

Những quyển sách tương tự

p53-cofactor JMY is a multifunctional actin nucleation factor.
Bằng: Zuchero, J, et al.
Được phát hành: (2009)

Mdm2 targets the p53 transcription cofactor JMY for degradation.
Bằng: Coutts, A, et al.
Được phát hành: (2007)

Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α.
Bằng: Coutts, A, et al.
Được phát hành: (2011)

Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α
Bằng: Coutts, A, et al.
Được phát hành: (2011)

JMY functions as actin nucleation-promoting factor and mediator for p53-mediated DNA damage in porcine oocytes.
Bằng: Zili Lin, et al.
Được phát hành: (2014-01-01)

The expression and cellular localization of phosphorylated VEGFR2 in lymphoma and non-neoplastic lymphadenopathy: an immunohistochemical study.
Bằng: Pillai, G, et al.
Được phát hành: (2005)

Actin nucleation by a transcription co-factor that links cytoskeletal events with the p53 response.
Bằng: Coutts, A, et al.
Được phát hành: (2010)

Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network.
Bằng: Weiwei Luo, et al.
Được phát hành: (2016-01-01)

Immunohistological recognition of cyclin D1 expression by non-lymphoid cells among lymphoid neoplastic cells
Bằng: Abdulla, Z, et al.
Được phát hành: (2014)

Immunohistological recognition of cyclin D1 expression by non-lymphoid cells among lymphoid neoplastic cells.
Bằng: Abdulla, Z, et al.
Được phát hành: (2014)

JMI 101 - Pengajian Islam
Bằng: PPPJJ, Pusat Pengajian Pendidikan Jarak Jauh
Được phát hành: (1999)

Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.
Bằng: Soilleux, E, et al.
Được phát hành: (2005)

Regulation of actin nucleation and autophagosome formation.
Bằng: Coutts, A, et al.
Được phát hành: (2016)

Reversible p53 expression in lung cancer.
Bằng: Pezzella, F, et al.
Được phát hành: (1992)

Actin nucleation by WH2 domains at the autophagosome.
Bằng: Coutts, A, et al.
Được phát hành: (2015)

Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival.
Bằng: Campo, L, et al.
Được phát hành: (2005)

p53 expression in normal paraffin-embedded tissue using different antibodies and antigen retrieval buffer systems.
Bằng: Pillai, G, et al.
Được phát hành: (2003)

Phosphorylated KDR can be located in the nucleus of neoplastic cells.
Bằng: Blazquez, C, et al.
Được phát hành: (2006)

Actin nucleators in the nucleus: an emerging theme.
Bằng: Weston, L, et al.
Được phát hành: (2012)

Antibody for detecting p53 protein by immunohistochemistry in normal tissues.
Bằng: Pezzella, F, et al.
Được phát hành: (1994)

Actin isoforms and neoplastic transformation
Bằng: V. B. Dugina, et al.
Được phát hành: (2017-04-01)

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer.
Bằng: Leek, R, et al.
Được phát hành: (1994)

The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis.
Bằng: Virginia L King, et al.
Được phát hành: (2021-04-01)

Why some tumours trigger neovascularisation and others don’t: the story thus far
Bằng: Adighibe, O, et al.
Được phát hành: (2016)

Loss of cytoplasmic actin filaments raises nuclear actin levels to drive INO80C-dependent chromosome fragmentation
Bằng: Verena Hurst, et al.
Được phát hành: (2024-11-01)

The Angiogenesis Regulator and Notch Pathway Activator Delta like Ligand 4 (DII4) Is Widely Expressed by Vascular and Neoplastic Cells in Human Cancer and Relocates to the Nucleus. An Immunohistochemical and In-Situ Hybridization Study
Bằng: Martinez, J, et al.
Được phát hành: (2009)

The Angiogenesis Regulator and Notch Pathway Activator Delta like Ligand 4 (DI14) Is Widely Expressed by Vascular and Neoplastic Cells in Human Cancer and Relocates to the Nucleus. An Immunohistochemical and In-Situ Hybridization Study
Bằng: Martinez, J, et al.
Được phát hành: (2009)

Nuclear and membrane expression of the angiogenesis regulator Delta Like Ligand 4(DLL4) in normal and malignant human tissues (Histopathology (2009) 54 (598-606))
Bằng: Turley, H, et al.
Được phát hành: (2009)

Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer.
Bằng: Tan, E, et al.
Được phát hành: (2007)

Biased localization of actin binding proteins by actin filament conformation
Bằng: Andrew R. Harris, et al.
Được phát hành: (2020-11-01)

Expression of angiogenic factors and hypoxia inducible factors HIF 1, HIF 2 and CA IX in non-Hodgkin's lymphoma.
Bằng: Stewart, M, et al.
Được phát hành: (2002)

Regulation of MRTF-A by JMY via a nucleation-independent mechanism
Bằng: Franziska Kluge, et al.
Được phát hành: (2018-11-01)

Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesis.
Bằng: Sivridis, E, et al.
Được phát hành: (2002)

p53 ubiquitination by Mdm2: a never ending tail?
Bằng: Coutts, A, et al.
Được phát hành: (2009)

Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues.
Bằng: Martinez, J, et al.
Được phát hành: (2009)

Vimentin filaments interact with the actin cortex in mitosis allowing normal cell division
Bằng: Sofia Duarte, et al.
Được phát hành: (2019-09-01)

The claudin gene family: expression in normal and neoplastic tissues
Bằng: Agarwal Rachana, et al.
Được phát hành: (2006-07-01)

Why some tumours trigger neovascularisation and others don’t: the story thus far
Bằng: Omanma Adighibe, et al.
Được phát hành: (2016-02-01)

A transcription co-factor integrates cell adhesion and motility with the p53 response.
Bằng: Coutts, A, et al.
Được phát hành: (2009)

Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments
Bằng: Takeru Torii, et al.
Được phát hành: (2023-11-01)