Genetic modification of primary human B cells generates translationally-relevant models of high-grade lymphoma

Abstract Sequencing studies of Diffuse Large B Cell Lymphoma (DLBCL) have identified hundreds of recurrently altered genes. However, it remains largely unknown whether and how these mutations may contribute to lymphomagenesis, either individually or in combination. Existing strategies to address thi...

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Detalhes bibliográficos
Principais autores: Caeser, R, Di Re, M, Krupka, J, Gao, J, Lara-Chica, M, Dias, JML, Cooke, S, Fenner, R, Usheva, Z, Runge, H, Beer, P, Eldaly, H, Pak, H-K, Park, C-S, Vassiliou, GS, Huntly, BJP, Mupo, A, Bashford-Rogers, RJM, Hodson, D
Formato: Journal article
Idioma:English
Publicado em: Nature Research 2019