Fabrication of nanoporous chitosan membranes

Naturally derived biopolymers have been widely used for biomedical applications such as drug carriers, wound dressings, and tissue engineering scaffolds. Chitosan is a typical polysaccharide of great interest due to its biocompatibility and film-formability. Chitosan membranes with controllable poro...

Ful tanımlama

Detaylı Bibliyografya
Asıl Yazarlar: Wang, X, Li, X, Stride, E, Edirisinghe, M
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 2010
_version_ 1826260476498018304
author Wang, X
Li, X
Stride, E
Edirisinghe, M
author_facet Wang, X
Li, X
Stride, E
Edirisinghe, M
author_sort Wang, X
collection OXFORD
description Naturally derived biopolymers have been widely used for biomedical applications such as drug carriers, wound dressings, and tissue engineering scaffolds. Chitosan is a typical polysaccharide of great interest due to its biocompatibility and film-formability. Chitosan membranes with controllable porous structures also have significant potential in membrane chromatography. Thus, the processing of membranes with porous nanoscale structures is of great importance, but it is also challenging and this has limited the application of these membranes to date. In this study, with the aid of a carefully selected surfactant, polyethyleneglycol stearate-40, chitosan membranes with a well controlled nanoscale structure were successfully prepared. Additional control over the membrane structure was obtained by exposing the suspension to high intensity, low frequency ultrasound. It was found that the concentration of chitosan/surfactant ratio and the ultrasound exposure conditions affect the structural features of the membranes. The stability of nanopores in the membrane was improved by intensive ultrasonication. Furthermore, the stability of the blended suspensions and the intermolecular interactions between chitosan and the surfactant were investigated using scanning electron microscope and Fourier transform infrared spectroscopy (FTIR) analysis, respectively. Hydrogen bonds and possible reaction sites for molecular interactions in the two polymers were also confirmed by FTIR analysis. © 2010 World Scientific Publishing Company.
first_indexed 2024-03-06T19:06:15Z
format Journal article
id oxford-uuid:153bbe75-163e-4cad-b8db-7e228a5fae90
institution University of Oxford
language English
last_indexed 2024-03-06T19:06:15Z
publishDate 2010
record_format dspace
spelling oxford-uuid:153bbe75-163e-4cad-b8db-7e228a5fae902022-03-26T10:24:16ZFabrication of nanoporous chitosan membranesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:153bbe75-163e-4cad-b8db-7e228a5fae90EnglishSymplectic Elements at Oxford2010Wang, XLi, XStride, EEdirisinghe, MNaturally derived biopolymers have been widely used for biomedical applications such as drug carriers, wound dressings, and tissue engineering scaffolds. Chitosan is a typical polysaccharide of great interest due to its biocompatibility and film-formability. Chitosan membranes with controllable porous structures also have significant potential in membrane chromatography. Thus, the processing of membranes with porous nanoscale structures is of great importance, but it is also challenging and this has limited the application of these membranes to date. In this study, with the aid of a carefully selected surfactant, polyethyleneglycol stearate-40, chitosan membranes with a well controlled nanoscale structure were successfully prepared. Additional control over the membrane structure was obtained by exposing the suspension to high intensity, low frequency ultrasound. It was found that the concentration of chitosan/surfactant ratio and the ultrasound exposure conditions affect the structural features of the membranes. The stability of nanopores in the membrane was improved by intensive ultrasonication. Furthermore, the stability of the blended suspensions and the intermolecular interactions between chitosan and the surfactant were investigated using scanning electron microscope and Fourier transform infrared spectroscopy (FTIR) analysis, respectively. Hydrogen bonds and possible reaction sites for molecular interactions in the two polymers were also confirmed by FTIR analysis. © 2010 World Scientific Publishing Company.
spellingShingle Wang, X
Li, X
Stride, E
Edirisinghe, M
Fabrication of nanoporous chitosan membranes
title Fabrication of nanoporous chitosan membranes
title_full Fabrication of nanoporous chitosan membranes
title_fullStr Fabrication of nanoporous chitosan membranes
title_full_unstemmed Fabrication of nanoporous chitosan membranes
title_short Fabrication of nanoporous chitosan membranes
title_sort fabrication of nanoporous chitosan membranes
work_keys_str_mv AT wangx fabricationofnanoporouschitosanmembranes
AT lix fabricationofnanoporouschitosanmembranes
AT stridee fabricationofnanoporouschitosanmembranes
AT edirisinghem fabricationofnanoporouschitosanmembranes