Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3

Although Poly(ADP-ribose)-polymerases (PARPs) are key regulators of genome stability, how site-specific ADP-ribosylation regulates DNA repair is unclear. Here, we describe a novel role for PARP1 and PARP2 in regulating Rad52-dependent replication fork repair to maintain cell viability when homologou...

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Bibliografski detalji
Glavni autori: Richards, F, Llorca-Cardenosa, MJ, Langton, J, Buch-Larson, SC, Shamki, NF, Sharma, AB, Nielsen, ML, Lakin, ND
Format: Journal article
Jezik:English
Izdano: Springer Nature 2023
Teme: