Detection of vaccine-induced antibodies to Ebola virus in oral fluid

Blood sampling to assess production of antigen-specific antibodies after immunization is commonly performed, but it presents logistical difficulties for trials carried out during an infectious disease outbreak. In this study, we show that antibodies may be reliably detected in oral fluid collected i...

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Bibliographic Details
Main Authors: Lambe, T, Rampling, T, Samuel, D, Bowyer, G, Ewer, K, Venkatraman, N, Edmans, M, Dicks, S, Hill, A, Tedder, R, Gilbert, S
Format: Journal article
Language:English
Published: Oxford University Press 2016
Description
Summary:Blood sampling to assess production of antigen-specific antibodies after immunization is commonly performed, but it presents logistical difficulties for trials carried out during an infectious disease outbreak. In this study, we show that antibodies may be reliably detected in oral fluid collected in a minimally invasive manner without use of sharps. Clinical Trials Registration. NCT02240875.