Chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate is associated with increased mortality and loss of ATP in rats after myocardial infarction.

Chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate is associated with increased mortality and loss of ATP in rats after myocardial infarction.

BACKGROUND: The failing myocardium is characterized by reductions of phosphocreatine (PCr) and free creatine content and by decreases of energy reserve via creatine kinase (CK), ie, CK reaction velocity (Flux(CK)). It has remained unclear whether these changes contribute directly to contractile dysf...

Bibliografski detalji
Glavni autori:	Horn, M, Remkes, H, Strömer, H, Dienesch, C, Neubauer, S
Format:	Journal article
Jezik:	English
Izdano:	2001

Slični predmeti

Functional and energetic consequences of chronic myocardial creatine depletion by beta-guanidinopropionate in perfused hearts and in intact rats.
od: Neubauer, S, i dr.
Izdano: (1999)

The effect of the creatine analogue beta-guanidinopropionic acid on energy metabolism: a systematic review.
od: Inge Oudman, i dr.
Izdano: (2013-01-01)

Chronic high-dose creatine feeding does not attenuate left ventricular remodeling in rat hearts post-myocardial infarction.
od: Horn, M, i dr.
Izdano: (1999)

Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy.
od: Neubauer, S, i dr.
Izdano: (1997)

Changes of creatine kinase gene expression in rat heart post-myocardial infarction.
od: Neubauer, S, i dr.
Izdano: (1998)

Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models
od: Kim Ji-Eun, i dr.
Izdano: (2010-10-01)

Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice.
od: Wallis, J, i dr.
Izdano: (2005)

Acute changes of myocardial creatine kinase gene expression under beta-adrenergic stimulation.
od: Hammerschmidt, S, i dr.
Izdano: (2000)

Preservation of cardiac function and energy reserve by the angiotensin-converting enzyme inhibitor quinapril during postmyocardial infarction remodeling in the rat.
od: Hügel, S, i dr.
Izdano: (2001)

Supernormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure - Insights from creatine transporter over-expression transgenic mice
od: Wallis, J, i dr.
Izdano: (2005)

Effects of ACE inhibition and beta-receptor blockade on energy metabolism in rats postmyocardial infarction.
od: Hügel, S, i dr.
Izdano: (1999)

Beta-guanidinopropionic acid does not extend Drosophila lifespan
od: Jonathan D. Dorigatti, i dr.
Izdano: (2021-09-01)

Mitochondrial creatine kinase is critically necessary for normal myocardial high-energy phosphate metabolism.
od: Spindler, M, i dr.
Izdano: (2002)

New insights into the creatine kinase-phosphocreatine energy buffer and transport system using mouse models of altered creatine content
od: Lygate, C, i dr.
Izdano: (2006)

High-dose 17beta-estradiol treatment prevents development of heart failure post-myocardial infarction in the rat.
od: Beer, S, i dr.
Izdano: (2007)

Evidence against a role of physiological concentrations of estrogen in post-myocardial infarction remodeling.
od: Hügel, S, i dr.
Izdano: (1999)

Manipulating creatine levels post-myocardial infarction--chronic effects on left ventricular remodeling.
od: Neubauer, S, i dr.
Izdano: (1998)

Effects of ACE inhibition and β-receptor blockade on energy metabolism in rats postmyocardial infarction
od: Hügel, S, i dr.
Izdano: (1999)

Effects of chronic dietary creatine feeding on cardiac energy metabolism and on creatine content in heart, skeletal muscle, brain, liver and kidney.
od: Horn, M, i dr.
Izdano: (1998)

Both Creatine and Its Product Phosphocreatine Reduce Oxidative Stress and Afford Neuroprotection in an Parkinson’s Model
od: Mauricio Peña Cunha, i dr.
Izdano: (2014-10-01)

Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine.
od: Boehm, E, i dr.
Izdano: (2003)

The Assertive Brain: Anterior Cingulate Phosphocreatine plus Creatine Levels Correlate With Self-Directedness in Healthy Adolescents
od: Letizia Squarcina, i dr.
Izdano: (2019-11-01)

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
od: Lygate, C, i dr.
Izdano: (2012)

GUANIDINOACETATE N-METHYLTRANSFERASE KNOCKOUT MICE EXHIBIT NORMAL LEFT VENTRICULAR REMODELLING, HAEMODYNAMICS AND SURVIVAL AFTER MYOCARDIAL INFARCTION DESPITE LACK OF PHOSPHOCREATINE
od: Lygate, C, i dr.
Izdano: (2010)

Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice
od: Lygate, C, i dr.
Izdano: (2013)

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
od: Lygate, C, i dr.
Izdano: (2013)

Absolute concentrations of cardiac high-energy phosphate metabolites ATP and phosphocreatine in heart failure: Relation to clinical severity and left ventricular function
od: Beer, M, i dr.
Izdano: (2001)

Myocardial energetics in obesity: Enhanced ATP delivery through creatine kinase with blunted stress response
od: Rayner, JJ, i dr.
Izdano: (2020)

Corrigendum: The Assertive Brain: Anterior Cingulate Phosphocreatine Plus Creatine Levels Correlate With Self-Directedness in Healthy Adolescents
od: Letizia Squarcina, i dr.
Izdano: (2020-01-01)

CARDIOPROTECTIVE EFFECTS OF PHOSPHOCREATINE
od: V. V. Lomivorotov, i dr.
Izdano: (2018-01-01)

Mechanisms of creatine depletion in chronically failing rat heart.
od: Ten Hove, M, i dr.
Izdano: (2005)

Myocardial creatine uptake is regulated by the sarcolemmal fraction of the creatine transporter, but not by the total creatine transporter pool
od: Boehm, E, i dr.
Izdano: (2002)

Detection of myocardial viability based on measurement of sodium content: A (23)Na-NMR study.
od: Horn, M, i dr.
Izdano: (2001)

Creatine kinase is associated with bleeding after myocardial infarction
od: Jesper Hastrup Svendsen, i dr.
Izdano: (2020-12-01)

Downregulation of the Na(+)-creatine cotransporter in failing human myocardium and in experimental heart failure.
od: Neubauer, S, i dr.
Izdano: (1999)

Regulation of Myocardial Creatine Uptake by Intra- and Extracellular Creatine Levels
od: Makinen, K, i dr.
Izdano: (2008)

Altered calcium homeostasis and increased susceptibility to ischemia in creatine kinase-deficient hearts
od: Spindler, M, i dr.
Izdano: (2002)

Long-term beta-blocker treatment prevents chronic creatine kinase and lactate dehydrogenase system changes in rat hearts after myocardial infarction.
od: Laser, A, i dr.
Izdano: (1996)

Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction
od: Yin Liu, i dr.
Izdano: (2024-04-01)

Fusogenic Liposomes for the Intracellular Delivery of Phosphocreatine
od: Okhil K. Nag, i dr.
Izdano: (2024-10-01)