Multiscale modelling of β-adrenergic stimulation in cardiac electromechanical function
β-adrenergic receptor stimulation (β-ARS) is a physiological mechanism that regulates cardiovascular function under stress conditions or physical exercise. Triggered during the so-called “fight-or-flight” response, the activation of the β-adrenergic receptors located on the cardiomyocyte membrane in...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2021
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| _version_ | 1797055171332669440 |
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| author | Doste, R Bueno Orovio, A |
| author_facet | Doste, R Bueno Orovio, A |
| author_sort | Doste, R |
| collection | OXFORD |
| description | β-adrenergic receptor stimulation (β-ARS) is a physiological mechanism that regulates cardiovascular function under stress conditions or physical exercise. Triggered during the so-called “fight-or-flight” response, the activation of the β-adrenergic receptors located on the cardiomyocyte membrane initiates a phosphorylation cascade of multiple ion channel targets that regulate both cellular excitability and recovery and of different proteins involved in intracellular calcium handling. As a result, β-ARS impacts both the electrophysiological and the mechanical response of the cardiomyocyte. β-ARS also plays a crucial role in several cardiac pathologies, greatly modifying cardiac output and potentially causing arrhythmogenic events. Mathematical patient-specific models are nowadays envisioned as an important tool for the personalised study of cardiac disease, the design of tailored treatments, or to inform risk assessment. Despite that, only a reduced number of computational studies of heart disease have incorporated β-ARS modelling. In this review, we describe the main existing multiscale frameworks to equip cellular models of cardiac electrophysiology with a β-ARS response. We also outline various applications of these multiscale frameworks in the study of cardiac pathology. We end with a discussion of the main current limitations and the future steps that need to be taken to adapt these models to a clinical environment and to incorporate them in organ-level simulations. |
| first_indexed | 2024-03-06T19:07:20Z |
| format | Journal article |
| id | oxford-uuid:1598c848-6b05-4d9e-801c-e19864307dfb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:07:20Z |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:1598c848-6b05-4d9e-801c-e19864307dfb2022-03-26T10:26:24ZMultiscale modelling of β-adrenergic stimulation in cardiac electromechanical functionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1598c848-6b05-4d9e-801c-e19864307dfbEnglishSymplectic ElementsMDPI2021Doste, RBueno Orovio, Aβ-adrenergic receptor stimulation (β-ARS) is a physiological mechanism that regulates cardiovascular function under stress conditions or physical exercise. Triggered during the so-called “fight-or-flight” response, the activation of the β-adrenergic receptors located on the cardiomyocyte membrane initiates a phosphorylation cascade of multiple ion channel targets that regulate both cellular excitability and recovery and of different proteins involved in intracellular calcium handling. As a result, β-ARS impacts both the electrophysiological and the mechanical response of the cardiomyocyte. β-ARS also plays a crucial role in several cardiac pathologies, greatly modifying cardiac output and potentially causing arrhythmogenic events. Mathematical patient-specific models are nowadays envisioned as an important tool for the personalised study of cardiac disease, the design of tailored treatments, or to inform risk assessment. Despite that, only a reduced number of computational studies of heart disease have incorporated β-ARS modelling. In this review, we describe the main existing multiscale frameworks to equip cellular models of cardiac electrophysiology with a β-ARS response. We also outline various applications of these multiscale frameworks in the study of cardiac pathology. We end with a discussion of the main current limitations and the future steps that need to be taken to adapt these models to a clinical environment and to incorporate them in organ-level simulations. |
| spellingShingle | Doste, R Bueno Orovio, A Multiscale modelling of β-adrenergic stimulation in cardiac electromechanical function |
| title | Multiscale modelling of β-adrenergic stimulation in cardiac electromechanical function |
| title_full | Multiscale modelling of β-adrenergic stimulation in cardiac electromechanical function |
| title_fullStr | Multiscale modelling of β-adrenergic stimulation in cardiac electromechanical function |
| title_full_unstemmed | Multiscale modelling of β-adrenergic stimulation in cardiac electromechanical function |
| title_short | Multiscale modelling of β-adrenergic stimulation in cardiac electromechanical function |
| title_sort | multiscale modelling of β adrenergic stimulation in cardiac electromechanical function |
| work_keys_str_mv | AT doster multiscalemodellingofbadrenergicstimulationincardiacelectromechanicalfunction AT buenoorovioa multiscalemodellingofbadrenergicstimulationincardiacelectromechanicalfunction |