Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis
NK cells are endowed with immunological memory to a range of pathogens but the development of NK cell memory in bacterial infections remains elusive. Here, we establish an assay inducing memory-like NK cell response to <i>Burkholderia pseudomallei</i>, the causative agent...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2023
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| _version_ | 1826312832851902464 |
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| author | Preechanukul, A Kronsteiner, B Saiprom, N Rochaikun, K Moonmueangsan, B Phunpang, R Ottiwet, O Kongphrai, Y Wapee, S Chotivanich, K Morakot, C Janon, R Dunachie, S Chantratita, N |
| author_facet | Preechanukul, A Kronsteiner, B Saiprom, N Rochaikun, K Moonmueangsan, B Phunpang, R Ottiwet, O Kongphrai, Y Wapee, S Chotivanich, K Morakot, C Janon, R Dunachie, S Chantratita, N |
| author_sort | Preechanukul, A |
| collection | OXFORD |
| description | NK cells are endowed with immunological memory to a range of pathogens but the development of NK cell memory in bacterial infections remains elusive. Here, we establish an assay inducing memory-like NK cell response to <i>Burkholderia pseudomallei</i>, the causative agent of the severe bacterial disease called melioidosis, and explore NK cell memory in a melioidosis patient cohort. We show that NK cells require bacteria-primed monocytes to acquire memory-like properties, demonstrated by bacteria-specific responses, features that strongly associate with CD160 expression. Induction of this memory-like NK cell is partly dependent on CD160 and IL-12R. Importantly, CD160 expression identifies memory-like NK cells in a cohort of recovered melioidosis patients with heightened responses maintained at least 3 months post hospital admission and reduced numbers of this cell population independently correlate with recurrent melioidosis. These newly identified memory-like NK cells are a promising target for future vaccine design and for monitoring protection against infection. |
| first_indexed | 2024-04-09T03:57:23Z |
| format | Journal article |
| id | oxford-uuid:15bc9ed3-2525-4c6f-beda-b78c343fb686 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:01:17Z |
| publishDate | 2023 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:15bc9ed3-2525-4c6f-beda-b78c343fb6862024-05-01T09:41:50ZIdentification and function of a novel human memory-like NK cell population expressing CD160 in melioidosisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:15bc9ed3-2525-4c6f-beda-b78c343fb686EnglishSymplectic ElementsCell Press2023Preechanukul, AKronsteiner, BSaiprom, NRochaikun, KMoonmueangsan, BPhunpang, ROttiwet, OKongphrai, YWapee, SChotivanich, KMorakot, CJanon, RDunachie, SChantratita, NNK cells are endowed with immunological memory to a range of pathogens but the development of NK cell memory in bacterial infections remains elusive. Here, we establish an assay inducing memory-like NK cell response to <i>Burkholderia pseudomallei</i>, the causative agent of the severe bacterial disease called melioidosis, and explore NK cell memory in a melioidosis patient cohort. We show that NK cells require bacteria-primed monocytes to acquire memory-like properties, demonstrated by bacteria-specific responses, features that strongly associate with CD160 expression. Induction of this memory-like NK cell is partly dependent on CD160 and IL-12R. Importantly, CD160 expression identifies memory-like NK cells in a cohort of recovered melioidosis patients with heightened responses maintained at least 3 months post hospital admission and reduced numbers of this cell population independently correlate with recurrent melioidosis. These newly identified memory-like NK cells are a promising target for future vaccine design and for monitoring protection against infection. |
| spellingShingle | Preechanukul, A Kronsteiner, B Saiprom, N Rochaikun, K Moonmueangsan, B Phunpang, R Ottiwet, O Kongphrai, Y Wapee, S Chotivanich, K Morakot, C Janon, R Dunachie, S Chantratita, N Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis |
| title | Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis |
| title_full | Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis |
| title_fullStr | Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis |
| title_full_unstemmed | Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis |
| title_short | Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis |
| title_sort | identification and function of a novel human memory like nk cell population expressing cd160 in melioidosis |
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