A systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy
<p><strong>Objectives:</strong> We conducted a systematic review and meta-analysis of studies that compared levels of molecular biomarkers in women with peripartum cardiomyopathy (PPCM) to those in healthy pregnant and postpartum women to: 1) assess the evidence for prolactin metab...
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
BMJ Publishing Group
2020
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| _version_ | 1826260571994980352 |
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| author | Cherubin, S Peoples, T Gillard, J Lakhal-Littleton, S Kurinczuk, J Nair, M |
| author_facet | Cherubin, S Peoples, T Gillard, J Lakhal-Littleton, S Kurinczuk, J Nair, M |
| author_sort | Cherubin, S |
| collection | OXFORD |
| description | <p><strong>Objectives:</strong> We conducted a systematic review and meta-analysis of studies that compared levels of molecular biomarkers in women with peripartum cardiomyopathy (PPCM) to those in healthy pregnant and postpartum women to: 1) assess the evidence for prolactin metabolism in PPCM, 2) ascertain the evidence for biomarkers of iron deficiency in PPCM , 3) identify other biomarkers associated with PPCM.</p>
<p><strong>Methods:</strong> We searched MEDLINE, EMBASE, CINAHL and the Global Health Library from inception without language restriction for studies that compared biomarkers levels in PPCM cases to healthy controls. Pooled Standardized Mean Difference (SMD) were generated using a random effects model for the difference in levels of biomarkers.</p>
<p><strong>Results:</strong> Two studies assessed the association of PRL with PPCM, and reported that PPCM cases have higher levels of total PRL. No studies investigated iron metabolism in PPCM. Other biomarkers associated with PPCM included serum levels of CRP (SMD: 2.281, 95% CI: 0.114; 4.448), white blood cells (SMD: 0.437, 95% CI: 0.095; 0.778), natriuretic peptides (SMD: 3.453, 95% CI: 2.174; 4.695), cardiac troponins (SMD: 1.108, 95% CI: 0.690; 1.526), liver enzymes (SMD: 0.651, 95% CI: 0.075; 1.228), and creatinine (SMD: 0.513, 95% CI: 0.33; 0.694), albumin (SMD: -0.662, 95% CI: - 0.971; -0.352), selenium (SMD: -0.744, 95% CI: -1.485; -0.002), and haemoglobin (SMD:-0.449, 95%CI: -0.639; -0.259).</p>
<p><strong>Conclusions:</strong> More robust molecular studies are needed to explore the association between prolactin and PPCM in human subjects and to determine the extent to which iron deficiency (with or without anaemia) contributes to the risk of PPCM.</p> |
| first_indexed | 2024-03-06T19:07:46Z |
| format | Journal article |
| id | oxford-uuid:15c0d8b9-a5e0-46dc-ad34-485ab90326b7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:07:46Z |
| publishDate | 2020 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:15c0d8b9-a5e0-46dc-ad34-485ab90326b72022-03-26T10:27:13ZA systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:15c0d8b9-a5e0-46dc-ad34-485ab90326b7EnglishSymplectic ElementsBMJ Publishing Group2020Cherubin, SPeoples, TGillard, JLakhal-Littleton, SKurinczuk, JNair, M<p><strong>Objectives:</strong> We conducted a systematic review and meta-analysis of studies that compared levels of molecular biomarkers in women with peripartum cardiomyopathy (PPCM) to those in healthy pregnant and postpartum women to: 1) assess the evidence for prolactin metabolism in PPCM, 2) ascertain the evidence for biomarkers of iron deficiency in PPCM , 3) identify other biomarkers associated with PPCM.</p> <p><strong>Methods:</strong> We searched MEDLINE, EMBASE, CINAHL and the Global Health Library from inception without language restriction for studies that compared biomarkers levels in PPCM cases to healthy controls. Pooled Standardized Mean Difference (SMD) were generated using a random effects model for the difference in levels of biomarkers.</p> <p><strong>Results:</strong> Two studies assessed the association of PRL with PPCM, and reported that PPCM cases have higher levels of total PRL. No studies investigated iron metabolism in PPCM. Other biomarkers associated with PPCM included serum levels of CRP (SMD: 2.281, 95% CI: 0.114; 4.448), white blood cells (SMD: 0.437, 95% CI: 0.095; 0.778), natriuretic peptides (SMD: 3.453, 95% CI: 2.174; 4.695), cardiac troponins (SMD: 1.108, 95% CI: 0.690; 1.526), liver enzymes (SMD: 0.651, 95% CI: 0.075; 1.228), and creatinine (SMD: 0.513, 95% CI: 0.33; 0.694), albumin (SMD: -0.662, 95% CI: - 0.971; -0.352), selenium (SMD: -0.744, 95% CI: -1.485; -0.002), and haemoglobin (SMD:-0.449, 95%CI: -0.639; -0.259).</p> <p><strong>Conclusions:</strong> More robust molecular studies are needed to explore the association between prolactin and PPCM in human subjects and to determine the extent to which iron deficiency (with or without anaemia) contributes to the risk of PPCM.</p> |
| spellingShingle | Cherubin, S Peoples, T Gillard, J Lakhal-Littleton, S Kurinczuk, J Nair, M A systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
| title | A systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
| title_full | A systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
| title_fullStr | A systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
| title_full_unstemmed | A systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
| title_short | A systematic review and meta-analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
| title_sort | systematic review and meta analysis of prolactin and iron deficiency in peripartum cardiomyopathy |
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