Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

<strong>Aims/hypothesis</strong> Pancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers insulin secretion in beta cells via oxidative mitochondrial pathways. However, it also feeds mitochondrial anap...

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Bibliographische Detailangaben
Hauptverfasser:	Cantley, J, Davenport, A, Vetterli, L, Nemes, N, Whitworth, P, Boslem, E, Thai, L, Mellett, N, Meikle, P, Hoehn, K, James, D, Biden, T
Format:	Journal article
Sprache:	English
Veröffentlicht:	Springer Verlag 2018

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