Pediatric Cushing's syndrome: clinical features, diagnosis, and treatment.
Cushing's syndrome (CS) results from prolonged exposure to supraphysiological levels of circulating glucocorticoids, endogenously or exogenously derived. Although rare in childhood, CS remains a difficult condition to diagnose and treat. A multidisciplinary approach and close collaboration with...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1797055348810448896 |
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| author | Chan, L Storr, H Grossman, AB Savage, M |
| author_facet | Chan, L Storr, H Grossman, AB Savage, M |
| author_sort | Chan, L |
| collection | OXFORD |
| description | Cushing's syndrome (CS) results from prolonged exposure to supraphysiological levels of circulating glucocorticoids, endogenously or exogenously derived. Although rare in childhood, CS remains a difficult condition to diagnose and treat. A multidisciplinary approach and close collaboration with adult colleagues is adopted at most large centres that manage pediatric CS patients. Although pediatric protocols are derived from adult data, significant differences exist between adult and childhood CS. Furthermore, long term outcome parameters including final height, bone mineral density, reproductive function, body composition and psychological health pose challenges for pediatric care. This article will aim to provide an overall view of pediatric CS highlighting some of the differences between adult and pediatric CS. |
| first_indexed | 2024-03-06T19:09:26Z |
| format | Journal article |
| id | oxford-uuid:16448ebb-a596-45c6-ae76-15dbf71eccec |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:09:26Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:16448ebb-a596-45c6-ae76-15dbf71eccec2022-03-26T10:30:15ZPediatric Cushing's syndrome: clinical features, diagnosis, and treatment.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:16448ebb-a596-45c6-ae76-15dbf71eccecEnglishSymplectic Elements at Oxford2007Chan, LStorr, HGrossman, ABSavage, MCushing's syndrome (CS) results from prolonged exposure to supraphysiological levels of circulating glucocorticoids, endogenously or exogenously derived. Although rare in childhood, CS remains a difficult condition to diagnose and treat. A multidisciplinary approach and close collaboration with adult colleagues is adopted at most large centres that manage pediatric CS patients. Although pediatric protocols are derived from adult data, significant differences exist between adult and childhood CS. Furthermore, long term outcome parameters including final height, bone mineral density, reproductive function, body composition and psychological health pose challenges for pediatric care. This article will aim to provide an overall view of pediatric CS highlighting some of the differences between adult and pediatric CS. |
| spellingShingle | Chan, L Storr, H Grossman, AB Savage, M Pediatric Cushing's syndrome: clinical features, diagnosis, and treatment. |
| title | Pediatric Cushing's syndrome: clinical features, diagnosis, and treatment. |
| title_full | Pediatric Cushing's syndrome: clinical features, diagnosis, and treatment. |
| title_fullStr | Pediatric Cushing's syndrome: clinical features, diagnosis, and treatment. |
| title_full_unstemmed | Pediatric Cushing's syndrome: clinical features, diagnosis, and treatment. |
| title_short | Pediatric Cushing's syndrome: clinical features, diagnosis, and treatment. |
| title_sort | pediatric cushing s syndrome clinical features diagnosis and treatment |
| work_keys_str_mv | AT chanl pediatriccushingssyndromeclinicalfeaturesdiagnosisandtreatment AT storrh pediatriccushingssyndromeclinicalfeaturesdiagnosisandtreatment AT grossmanab pediatriccushingssyndromeclinicalfeaturesdiagnosisandtreatment AT savagem pediatriccushingssyndromeclinicalfeaturesdiagnosisandtreatment |