MT1-MMP: a potent modifier of pericellular microenvironment.
Cells are regulated by many different means, and there is more and more evidence emerging that changes in the microenvironment greatly affect cell function. MT1-MMP is a type I transmembrane proteinase which participates in pericellular proteolysis of extracellular matrix (ECM) macromolecules. The e...
| Główni autorzy: | , |
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| Format: | Journal article |
| Język: | English |
| Wydane: |
2006
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| _version_ | 1826260675084681216 |
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| author | Itoh, Y Seiki, M |
| author_facet | Itoh, Y Seiki, M |
| author_sort | Itoh, Y |
| collection | OXFORD |
| description | Cells are regulated by many different means, and there is more and more evidence emerging that changes in the microenvironment greatly affect cell function. MT1-MMP is a type I transmembrane proteinase which participates in pericellular proteolysis of extracellular matrix (ECM) macromolecules. The enzyme is cellular collagenase essential for skeletal development, cancer invasion, growth, and angiogenesis. MT1-MMP promotes cell invasion and motility by pericellular ECM degradation, shedding of CD44 and syndecan1, and by activating ERK. Thus MT1-MMP is one of the factors that influence the cellular microenvironment and thereby affect cell-signaling pathways and eventually alters cellular behavior. As a proteinase, MT1-MMP is regulated by inhibitors, but it also requires formation of a homo-oligomer complex, localization to migration front of the cells, and internalization to become a "functionally active" cell function modifier. Developing new means to inhibit "functional activity" of MT1-MMP may be a new direction to establish treatments for the diseases that MT1-MMP mediates such as cancer and rheumatoid arthritis. |
| first_indexed | 2024-03-06T19:09:26Z |
| format | Journal article |
| id | oxford-uuid:1646a166-7cb9-4f8e-8c83-507e28f97fbd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:09:26Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:1646a166-7cb9-4f8e-8c83-507e28f97fbd2022-03-26T10:30:17ZMT1-MMP: a potent modifier of pericellular microenvironment.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1646a166-7cb9-4f8e-8c83-507e28f97fbdEnglishSymplectic Elements at Oxford2006Itoh, YSeiki, MCells are regulated by many different means, and there is more and more evidence emerging that changes in the microenvironment greatly affect cell function. MT1-MMP is a type I transmembrane proteinase which participates in pericellular proteolysis of extracellular matrix (ECM) macromolecules. The enzyme is cellular collagenase essential for skeletal development, cancer invasion, growth, and angiogenesis. MT1-MMP promotes cell invasion and motility by pericellular ECM degradation, shedding of CD44 and syndecan1, and by activating ERK. Thus MT1-MMP is one of the factors that influence the cellular microenvironment and thereby affect cell-signaling pathways and eventually alters cellular behavior. As a proteinase, MT1-MMP is regulated by inhibitors, but it also requires formation of a homo-oligomer complex, localization to migration front of the cells, and internalization to become a "functionally active" cell function modifier. Developing new means to inhibit "functional activity" of MT1-MMP may be a new direction to establish treatments for the diseases that MT1-MMP mediates such as cancer and rheumatoid arthritis. |
| spellingShingle | Itoh, Y Seiki, M MT1-MMP: a potent modifier of pericellular microenvironment. |
| title | MT1-MMP: a potent modifier of pericellular microenvironment. |
| title_full | MT1-MMP: a potent modifier of pericellular microenvironment. |
| title_fullStr | MT1-MMP: a potent modifier of pericellular microenvironment. |
| title_full_unstemmed | MT1-MMP: a potent modifier of pericellular microenvironment. |
| title_short | MT1-MMP: a potent modifier of pericellular microenvironment. |
| title_sort | mt1 mmp a potent modifier of pericellular microenvironment |
| work_keys_str_mv | AT itohy mt1mmpapotentmodifierofpericellularmicroenvironment AT seikim mt1mmpapotentmodifierofpericellularmicroenvironment |