The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers.
Apomorphine, a non-selective dopamine agonist, has been used as a pharmacological probe for investigating central dopaminergic neurotransmission in psychiatric illness. In this study repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the ad...
| Main Authors: | , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
1993
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| _version_ | 1826260712027062272 |
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| author | Grasby, P Friston, K Bench, C Cowen, P Frith, C Liddle, P Frackowiak, R Dolan, R |
| author_facet | Grasby, P Friston, K Bench, C Cowen, P Frith, C Liddle, P Frackowiak, R Dolan, R |
| author_sort | Grasby, P |
| collection | OXFORD |
| description | Apomorphine, a non-selective dopamine agonist, has been used as a pharmacological probe for investigating central dopaminergic neurotransmission in psychiatric illness. In this study repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the administration of apomorphine (5 or 10 micrograms/kg), or placebo. The difference in rCBF, before and after drug (apomorphine versus placebo), was used to identify brain areas affected by apomorphine. Compared to placebo, both doses of apomorphine increased blood flow in the anterior cingulate cortex. Apomorphine 10 micrograms/kg also increased prefrontal rCBF (right > left). No decreases in rCBF were noted following either dose of apomorphine. Apomorphine-induced increases of anterior cingulate blood flow might serve as an in vivo index of central dopamine function. Such an approach would complement established neuroendocrine challenge paradigms for investigating central dopamine neurotransmission in psychiatric illness. |
| first_indexed | 2024-03-06T19:10:02Z |
| format | Journal article |
| id | oxford-uuid:167345f7-7cfa-4d9e-be76-3c4039b7b1a2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:10:02Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:167345f7-7cfa-4d9e-be76-3c4039b7b1a22022-03-26T10:31:23ZThe effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:167345f7-7cfa-4d9e-be76-3c4039b7b1a2EnglishSymplectic Elements at Oxford1993Grasby, PFriston, KBench, CCowen, PFrith, CLiddle, PFrackowiak, RDolan, RApomorphine, a non-selective dopamine agonist, has been used as a pharmacological probe for investigating central dopaminergic neurotransmission in psychiatric illness. In this study repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the administration of apomorphine (5 or 10 micrograms/kg), or placebo. The difference in rCBF, before and after drug (apomorphine versus placebo), was used to identify brain areas affected by apomorphine. Compared to placebo, both doses of apomorphine increased blood flow in the anterior cingulate cortex. Apomorphine 10 micrograms/kg also increased prefrontal rCBF (right > left). No decreases in rCBF were noted following either dose of apomorphine. Apomorphine-induced increases of anterior cingulate blood flow might serve as an in vivo index of central dopamine function. Such an approach would complement established neuroendocrine challenge paradigms for investigating central dopamine neurotransmission in psychiatric illness. |
| spellingShingle | Grasby, P Friston, K Bench, C Cowen, P Frith, C Liddle, P Frackowiak, R Dolan, R The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers. |
| title | The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers. |
| title_full | The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers. |
| title_fullStr | The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers. |
| title_full_unstemmed | The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers. |
| title_short | The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers. |
| title_sort | effect of the dopamine agonist apomorphine on regional cerebral blood flow in normal volunteers |
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