Neuropathic pain is a feature in patients with symptomatic femoral acetabular impingement
<p>Femoral acetabular impingement syndrome (FAIS) is a cause of hip pain thought to be nociceptive, although pain phenotypes e.g., burning, pain attacks, prickling, numbness etc., are reported, mimicking neuropathic pain. Although no lesion to the somatosensory system is identified, neuropathi...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2024
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| _version_ | 1824458660655398912 |
|---|---|
| author | Wood, S Coxon, L Glyn-Jones, S Barker, KL |
| author_facet | Wood, S Coxon, L Glyn-Jones, S Barker, KL |
| author_sort | Wood, S |
| collection | OXFORD |
| description | <p>Femoral acetabular impingement syndrome (FAIS) is a cause of hip pain thought to be nociceptive, although pain phenotypes e.g., burning, pain attacks, prickling, numbness etc., are reported, mimicking neuropathic pain. Although no lesion to the somatosensory system is identified, neuropathic pain (NeP) may explain why nociceptive-focussed treatments are not always successful.</p>
<p><strong>Objective: </strong>To identify NeP in patients with FAIS and investigate if related to poorer outcomes.</p>
<p><strong>Design: </strong>A secondary analysis of the Femoral Acetabular Impingement Trial (FAIT). Outcome of interest: PainDETECT questionnaire; secondary outcomes of interest; International Hip Outcome Tool (iHOT33), Hospital Anxiety and Depression Scale (HADS) and VAS ‘average pain over a month’, at baseline and 8 months follow-up. Intervention (surgery or physiotherapy) were pooled.</p>
<p><strong>Results: </strong>173 data sets at baseline; 123 at 8 months follow-up. Baseline painDETECT identified three groups: 69% nociceptive, 19% unclear and 12% neuropathic pain phenotypes. Baseline, median scores were higher for the neuropathic group compared to the nociceptive group demonstrating borderline anxiety (9.5(5.3 to 14.2), 5(3 to 8), higher normal values for depression (7.5(2.3 to 11.8), (4(2 to 9), higher average pain (7 (6 to 8), 5(4 to 6) and lower iHOT33 14.2(9 to 21.1), 38.4(26.2 to 55.7). Post treatment, there was a median change in the neuropathic score in both iHOT33 (40.8 (25 to 76.5) with a median difference of 24.13 (CI 95% 10.46 to 45.92) and average pain 4.5(1.5 to 7) with a median difference of 2 (CI 95% 1 to 5) but to a lesser amount than the nociceptive group, iHOT33 (64(38.2 to 86.6) with a median difference of 15.50 (CI 95% 6.41 to 21.82) and average pain 3(1 to 5.7) with a median difference of 1 (CI 95% 0.5 to 1).</p>
<p><strong>Conclusion: </strong>NeP exists in symptomatic FAIS patients and is associated with increased average pain, and functional limitations. Nociceptive-targeted treatment improves hip function and pain but with less improvement in the NeP group when compared to the nociceptive group.</p>
<div>Pain phenotyping before intervention may improve outcomes.</div>
<p><strong>Contribution of paper:</strong></p>
<ul>
<li>Neuropathic pain is a feature in patients with Femoral Acetabular Impingement Syndrome (FAIS).</li>
<li>Neuropathic pain is related to borderline levels of anxiety, higher average pain and poorer hip function.</li>
<li>Nociceptive focused treatment improves hip function and average pain in patients with neuropathic pain but to a lesser extent than patients with nociceptive pain.</li>
</ul> |
| first_indexed | 2025-02-19T04:29:25Z |
| format | Journal article |
| id | oxford-uuid:1687a0f3-bd60-4438-b187-d0d280f1cf6a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:29:25Z |
| publishDate | 2024 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:1687a0f3-bd60-4438-b187-d0d280f1cf6a2024-12-19T14:06:50ZNeuropathic pain is a feature in patients with symptomatic femoral acetabular impingementJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1687a0f3-bd60-4438-b187-d0d280f1cf6aEnglishSymplectic ElementsElsevier2024Wood, SCoxon, LGlyn-Jones, SBarker, KL<p>Femoral acetabular impingement syndrome (FAIS) is a cause of hip pain thought to be nociceptive, although pain phenotypes e.g., burning, pain attacks, prickling, numbness etc., are reported, mimicking neuropathic pain. Although no lesion to the somatosensory system is identified, neuropathic pain (NeP) may explain why nociceptive-focussed treatments are not always successful.</p> <p><strong>Objective: </strong>To identify NeP in patients with FAIS and investigate if related to poorer outcomes.</p> <p><strong>Design: </strong>A secondary analysis of the Femoral Acetabular Impingement Trial (FAIT). Outcome of interest: PainDETECT questionnaire; secondary outcomes of interest; International Hip Outcome Tool (iHOT33), Hospital Anxiety and Depression Scale (HADS) and VAS ‘average pain over a month’, at baseline and 8 months follow-up. Intervention (surgery or physiotherapy) were pooled.</p> <p><strong>Results: </strong>173 data sets at baseline; 123 at 8 months follow-up. Baseline painDETECT identified three groups: 69% nociceptive, 19% unclear and 12% neuropathic pain phenotypes. Baseline, median scores were higher for the neuropathic group compared to the nociceptive group demonstrating borderline anxiety (9.5(5.3 to 14.2), 5(3 to 8), higher normal values for depression (7.5(2.3 to 11.8), (4(2 to 9), higher average pain (7 (6 to 8), 5(4 to 6) and lower iHOT33 14.2(9 to 21.1), 38.4(26.2 to 55.7). Post treatment, there was a median change in the neuropathic score in both iHOT33 (40.8 (25 to 76.5) with a median difference of 24.13 (CI 95% 10.46 to 45.92) and average pain 4.5(1.5 to 7) with a median difference of 2 (CI 95% 1 to 5) but to a lesser amount than the nociceptive group, iHOT33 (64(38.2 to 86.6) with a median difference of 15.50 (CI 95% 6.41 to 21.82) and average pain 3(1 to 5.7) with a median difference of 1 (CI 95% 0.5 to 1).</p> <p><strong>Conclusion: </strong>NeP exists in symptomatic FAIS patients and is associated with increased average pain, and functional limitations. Nociceptive-targeted treatment improves hip function and pain but with less improvement in the NeP group when compared to the nociceptive group.</p> <div>Pain phenotyping before intervention may improve outcomes.</div> <p><strong>Contribution of paper:</strong></p> <ul> <li>Neuropathic pain is a feature in patients with Femoral Acetabular Impingement Syndrome (FAIS).</li> <li>Neuropathic pain is related to borderline levels of anxiety, higher average pain and poorer hip function.</li> <li>Nociceptive focused treatment improves hip function and average pain in patients with neuropathic pain but to a lesser extent than patients with nociceptive pain.</li> </ul> |
| spellingShingle | Wood, S Coxon, L Glyn-Jones, S Barker, KL Neuropathic pain is a feature in patients with symptomatic femoral acetabular impingement |
| title | Neuropathic pain is a feature in patients with symptomatic femoral acetabular impingement |
| title_full | Neuropathic pain is a feature in patients with symptomatic femoral acetabular impingement |
| title_fullStr | Neuropathic pain is a feature in patients with symptomatic femoral acetabular impingement |
| title_full_unstemmed | Neuropathic pain is a feature in patients with symptomatic femoral acetabular impingement |
| title_short | Neuropathic pain is a feature in patients with symptomatic femoral acetabular impingement |
| title_sort | neuropathic pain is a feature in patients with symptomatic femoral acetabular impingement |
| work_keys_str_mv | AT woods neuropathicpainisafeatureinpatientswithsymptomaticfemoralacetabularimpingement AT coxonl neuropathicpainisafeatureinpatientswithsymptomaticfemoralacetabularimpingement AT glynjoness neuropathicpainisafeatureinpatientswithsymptomaticfemoralacetabularimpingement AT barkerkl neuropathicpainisafeatureinpatientswithsymptomaticfemoralacetabularimpingement |