Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells
Murine CMV (MCMV) infection induces effector CD8(+) T cells that continue to increase in frequency after acute infection ("inflation") and are stably maintained at a high frequency, with up to 20% of the CD8(+) T-cell compartment being specific for one epitope, although the flexibility and...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2015
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| _version_ | 1797055413169946624 |
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| author | Sims, S Bolinger, B Klenerman, P |
| author_facet | Sims, S Bolinger, B Klenerman, P |
| author_sort | Sims, S |
| collection | OXFORD |
| description | Murine CMV (MCMV) infection induces effector CD8(+) T cells that continue to increase in frequency after acute infection ("inflation") and are stably maintained at a high frequency, with up to 20% of the CD8(+) T-cell compartment being specific for one epitope, although the flexibility and turnover of these populations is not fully defined. Here we report that effector/memory CD8(+) T cells induced by MCMV can be paradoxically boosted following transient depletion of epitope specific CD8(+) T cells. Treatment of MCMV-infected mice with MHC-Class I-saporin tetramers led to partial (80-90%) depletion of epitope-specific CD8(+) T cells-rapidly followed by a rebound, leading to expansion and maintenance of up to 40% of total CD8(+) T cells, with minimal changes in response to a control epitope (M45). These data indicate the tight balance between host and virus during persistent infection and the functional flexibility of the "inflated" CD8(+) T cell responses during persistent infection. |
| first_indexed | 2024-03-06T19:10:22Z |
| format | Journal article |
| id | oxford-uuid:1692c16e-cbb5-48a0-ac96-72a8e52cb3ae |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:10:22Z |
| publishDate | 2015 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:1692c16e-cbb5-48a0-ac96-72a8e52cb3ae2022-03-26T10:31:58ZIncreasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cellsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1692c16e-cbb5-48a0-ac96-72a8e52cb3aeEnglishSymplectic Elements at OxfordWiley2015Sims, SBolinger, BKlenerman, PMurine CMV (MCMV) infection induces effector CD8(+) T cells that continue to increase in frequency after acute infection ("inflation") and are stably maintained at a high frequency, with up to 20% of the CD8(+) T-cell compartment being specific for one epitope, although the flexibility and turnover of these populations is not fully defined. Here we report that effector/memory CD8(+) T cells induced by MCMV can be paradoxically boosted following transient depletion of epitope specific CD8(+) T cells. Treatment of MCMV-infected mice with MHC-Class I-saporin tetramers led to partial (80-90%) depletion of epitope-specific CD8(+) T cells-rapidly followed by a rebound, leading to expansion and maintenance of up to 40% of total CD8(+) T cells, with minimal changes in response to a control epitope (M45). These data indicate the tight balance between host and virus during persistent infection and the functional flexibility of the "inflated" CD8(+) T cell responses during persistent infection. |
| spellingShingle | Sims, S Bolinger, B Klenerman, P Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells |
| title | Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells |
| title_full | Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells |
| title_fullStr | Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells |
| title_full_unstemmed | Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells |
| title_short | Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells |
| title_sort | increasing inflationary t cell responses following transient depletion of mcmv specific memory t cells |
| work_keys_str_mv | AT simss increasinginflationarytcellresponsesfollowingtransientdepletionofmcmvspecificmemorytcells AT bolingerb increasinginflationarytcellresponsesfollowingtransientdepletionofmcmvspecificmemorytcells AT klenermanp increasinginflationarytcellresponsesfollowingtransientdepletionofmcmvspecificmemorytcells |