Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.1...

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Bibliographic Details
Main Authors: Thye, T, Vannberg, F, Wong, S, Owusu-Dabo, E, Osei, I, Gyapong, J, Sirugo, G, Sisay-Joof, F, Enimil, A, Chinbuah, M, Floyd, S, Warndorff, D, Sichali, L, Malema, S, Crampin, A, Ngwira, B, Teo, Y, Small, K, Rockett, K, Kwiatkowski, D, Fine, P, Hill, P, Newport, M, Lienhardt, C, Adegbola, R
Format: Journal article
Language:English
Published: 2010
Description
Summary:We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

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