Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.1...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1826260751412625408 |
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| author | Thye, T Vannberg, F Wong, S Owusu-Dabo, E Osei, I Gyapong, J Sirugo, G Sisay-Joof, F Enimil, A Chinbuah, M Floyd, S Warndorff, D Sichali, L Malema, S Crampin, A Ngwira, B Teo, Y Small, K Rockett, K Kwiatkowski, D Fine, P Hill, P Newport, M Lienhardt, C Adegbola, R |
| author_facet | Thye, T Vannberg, F Wong, S Owusu-Dabo, E Osei, I Gyapong, J Sirugo, G Sisay-Joof, F Enimil, A Chinbuah, M Floyd, S Warndorff, D Sichali, L Malema, S Crampin, A Ngwira, B Teo, Y Small, K Rockett, K Kwiatkowski, D Fine, P Hill, P Newport, M Lienhardt, C Adegbola, R |
| author_sort | Thye, T |
| collection | OXFORD |
| description | We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low. |
| first_indexed | 2024-03-06T19:10:39Z |
| format | Journal article |
| id | oxford-uuid:16a8ea4b-aaf1-4a4f-bc28-a12a04d69109 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:10:39Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:16a8ea4b-aaf1-4a4f-bc28-a12a04d691092022-03-26T10:32:41ZGenome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:16a8ea4b-aaf1-4a4f-bc28-a12a04d69109EnglishSymplectic Elements at Oxford2010Thye, TVannberg, FWong, SOwusu-Dabo, EOsei, IGyapong, JSirugo, GSisay-Joof, FEnimil, AChinbuah, MFloyd, SWarndorff, DSichali, LMalema, SCrampin, ANgwira, BTeo, YSmall, KRockett, KKwiatkowski, DFine, PHill, PNewport, MLienhardt, CAdegbola, RWe combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low. |
| spellingShingle | Thye, T Vannberg, F Wong, S Owusu-Dabo, E Osei, I Gyapong, J Sirugo, G Sisay-Joof, F Enimil, A Chinbuah, M Floyd, S Warndorff, D Sichali, L Malema, S Crampin, A Ngwira, B Teo, Y Small, K Rockett, K Kwiatkowski, D Fine, P Hill, P Newport, M Lienhardt, C Adegbola, R Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. |
| title | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. |
| title_full | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. |
| title_fullStr | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. |
| title_full_unstemmed | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. |
| title_short | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. |
| title_sort | genome wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11 2 |
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