Abnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect.
Brain regions beyond visual cortex are thought to be responsible for attention-related modulation of visual processing [1, 2], but most evidence is indirect. Here, we applied functional magnetic resonance imaging (fMRI), including retinotopic mapping of visual areas, to patients with focal right-par...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1826260767149654016 |
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| author | Vuilleumier, P Schwartz, S Verdon, V Maravita, A Hutton, C Husain, M Driver, J |
| author_facet | Vuilleumier, P Schwartz, S Verdon, V Maravita, A Hutton, C Husain, M Driver, J |
| author_sort | Vuilleumier, P |
| collection | OXFORD |
| description | Brain regions beyond visual cortex are thought to be responsible for attention-related modulation of visual processing [1, 2], but most evidence is indirect. Here, we applied functional magnetic resonance imaging (fMRI), including retinotopic mapping of visual areas, to patients with focal right-parietal lesions and left spatial neglect [3, 4]. When attentional load at fixation was minimal, retinotopic areas in right visual cortex showed preserved responses to task-irrelevant checkerboards in the contralateral left hemifield, analogously to left visual cortex for right-hemifield checkerboards, indicating a "symmetric" pattern in both hemispheres with respect to contralateral stimulation under these conditions. But when attentional load at fixation was increased, a functional asymmetry emerged for visual cortex, with contralateral responses in right visual areas being pathologically reduced (even eliminated for right V4/TEO), whereas left visual areas showed no such reduction in their contralateral response. These results reveal attention-dependent abnormalities in visual cortex after lesions in distant (parietal) regions. This may explain otherwise puzzling aspects of neglect [5, 6], as confirmed here by additional behavioral testing. |
| first_indexed | 2024-03-06T19:10:55Z |
| format | Journal article |
| id | oxford-uuid:16bce13d-f4a0-490c-a0e9-3092e3fb22f2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:10:55Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:16bce13d-f4a0-490c-a0e9-3092e3fb22f22022-03-26T10:33:04ZAbnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:16bce13d-f4a0-490c-a0e9-3092e3fb22f2EnglishSymplectic Elements at Oxford2008Vuilleumier, PSchwartz, SVerdon, VMaravita, AHutton, CHusain, MDriver, JBrain regions beyond visual cortex are thought to be responsible for attention-related modulation of visual processing [1, 2], but most evidence is indirect. Here, we applied functional magnetic resonance imaging (fMRI), including retinotopic mapping of visual areas, to patients with focal right-parietal lesions and left spatial neglect [3, 4]. When attentional load at fixation was minimal, retinotopic areas in right visual cortex showed preserved responses to task-irrelevant checkerboards in the contralateral left hemifield, analogously to left visual cortex for right-hemifield checkerboards, indicating a "symmetric" pattern in both hemispheres with respect to contralateral stimulation under these conditions. But when attentional load at fixation was increased, a functional asymmetry emerged for visual cortex, with contralateral responses in right visual areas being pathologically reduced (even eliminated for right V4/TEO), whereas left visual areas showed no such reduction in their contralateral response. These results reveal attention-dependent abnormalities in visual cortex after lesions in distant (parietal) regions. This may explain otherwise puzzling aspects of neglect [5, 6], as confirmed here by additional behavioral testing. |
| spellingShingle | Vuilleumier, P Schwartz, S Verdon, V Maravita, A Hutton, C Husain, M Driver, J Abnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect. |
| title | Abnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect. |
| title_full | Abnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect. |
| title_fullStr | Abnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect. |
| title_full_unstemmed | Abnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect. |
| title_short | Abnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect. |
| title_sort | abnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect |
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