Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex.
Uncertainty about the function of orbitofrontal cortex (OFC) in guiding decision-making may be a result of its medial (mOFC) and lateral (lOFC) divisions having distinct functions. Here we test the hypothesis that the mOFC is more concerned with reward-guided decision making, in contrast with the lO...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826260787611566080 |
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| author | Noonan, M Walton, M Behrens, T Sallet, J Buckley, M Rushworth, M |
| author_facet | Noonan, M Walton, M Behrens, T Sallet, J Buckley, M Rushworth, M |
| author_sort | Noonan, M |
| collection | OXFORD |
| description | Uncertainty about the function of orbitofrontal cortex (OFC) in guiding decision-making may be a result of its medial (mOFC) and lateral (lOFC) divisions having distinct functions. Here we test the hypothesis that the mOFC is more concerned with reward-guided decision making, in contrast with the lOFC's role in reward-guided learning. Macaques performed three-armed bandit tasks and the effects of selective mOFC lesions were contrasted against lOFC lesions. First, we present analyses that make it possible to measure reward-credit assignment--a crucial component of reward-value learning--independently of the decisions animals make. The mOFC lesions do not lead to impairments in reward-credit assignment that are seen after lOFC lesions. Second, we examined how the reward values of choice options were compared. We present three analyses, one of which examines reward-guided decision making independently of reward-value learning. Lesions of the mOFC, but not the lOFC, disrupted reward-guided decision making. Impairments after mOFC lesions were a function of the multiple option contexts in which decisions were made. Contrary to axiomatic assumptions of decision theory, the mOFC-lesioned animals' value comparisons were no longer independent of irrelevant alternatives. |
| first_indexed | 2024-03-06T19:11:16Z |
| format | Journal article |
| id | oxford-uuid:16d8697c-13c9-42bc-a7a8-0b5bcd8b6e69 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:11:16Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:16d8697c-13c9-42bc-a7a8-0b5bcd8b6e692022-03-26T10:33:45ZSeparate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:16d8697c-13c9-42bc-a7a8-0b5bcd8b6e69EnglishSymplectic Elements at Oxford2010Noonan, MWalton, MBehrens, TSallet, JBuckley, MRushworth, MUncertainty about the function of orbitofrontal cortex (OFC) in guiding decision-making may be a result of its medial (mOFC) and lateral (lOFC) divisions having distinct functions. Here we test the hypothesis that the mOFC is more concerned with reward-guided decision making, in contrast with the lOFC's role in reward-guided learning. Macaques performed three-armed bandit tasks and the effects of selective mOFC lesions were contrasted against lOFC lesions. First, we present analyses that make it possible to measure reward-credit assignment--a crucial component of reward-value learning--independently of the decisions animals make. The mOFC lesions do not lead to impairments in reward-credit assignment that are seen after lOFC lesions. Second, we examined how the reward values of choice options were compared. We present three analyses, one of which examines reward-guided decision making independently of reward-value learning. Lesions of the mOFC, but not the lOFC, disrupted reward-guided decision making. Impairments after mOFC lesions were a function of the multiple option contexts in which decisions were made. Contrary to axiomatic assumptions of decision theory, the mOFC-lesioned animals' value comparisons were no longer independent of irrelevant alternatives. |
| spellingShingle | Noonan, M Walton, M Behrens, T Sallet, J Buckley, M Rushworth, M Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex. |
| title | Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex. |
| title_full | Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex. |
| title_fullStr | Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex. |
| title_full_unstemmed | Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex. |
| title_short | Separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex. |
| title_sort | separate value comparison and learning mechanisms in macaque medial and lateral orbitofrontal cortex |
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