Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid
Butane-2,3-diacetal (BDA) desymmetrised glycolic acid building block 1 undergoes highly diastereoselective lithium enolate ketone aldol reactions with a range of methyl and mono-substituted methyl ketones to yield, after acid-catalysed deprotection, enantiopure α,β-dihydroxy acid derivatives bearing...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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| _version_ | 1797055494247940096 |
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| author | Dixon, D Guarna, A Ley, S Polara, A Rodriguez, F |
| author_facet | Dixon, D Guarna, A Ley, S Polara, A Rodriguez, F |
| author_sort | Dixon, D |
| collection | OXFORD |
| description | Butane-2,3-diacetal (BDA) desymmetrised glycolic acid building block 1 undergoes highly diastereoselective lithium enolate ketone aldol reactions with a range of methyl and mono-substituted methyl ketones to yield, after acid-catalysed deprotection, enantiopure α,β-dihydroxy acid derivatives bearing a quaternary carbon atom at the β-hydroxy centre. |
| first_indexed | 2024-03-06T19:11:28Z |
| format | Journal article |
| id | oxford-uuid:16ec88a5-d892-43cf-a10c-a2edcdf5ce8f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:11:28Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:16ec88a5-d892-43cf-a10c-a2edcdf5ce8f2022-03-26T10:34:07ZHighly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acidJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:16ec88a5-d892-43cf-a10c-a2edcdf5ce8fEnglishSymplectic Elements at Oxford2002Dixon, DGuarna, ALey, SPolara, ARodriguez, FButane-2,3-diacetal (BDA) desymmetrised glycolic acid building block 1 undergoes highly diastereoselective lithium enolate ketone aldol reactions with a range of methyl and mono-substituted methyl ketones to yield, after acid-catalysed deprotection, enantiopure α,β-dihydroxy acid derivatives bearing a quaternary carbon atom at the β-hydroxy centre. |
| spellingShingle | Dixon, D Guarna, A Ley, S Polara, A Rodriguez, F Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid |
| title | Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid |
| title_full | Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid |
| title_fullStr | Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid |
| title_full_unstemmed | Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid |
| title_short | Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid |
| title_sort | highly diastereoselective ketone aldol reactions of butane 2 3 diacetal desymmetrised glycolic acid |
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