Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid

Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid

Butane-2,3-diacetal (BDA) desymmetrised glycolic acid building block 1 undergoes highly diastereoselective lithium enolate ketone aldol reactions with a range of methyl and mono-substituted methyl ketones to yield, after acid-catalysed deprotection, enantiopure α,β-dihydroxy acid derivatives bearing...

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Bibliographic Details
Main Authors:	Dixon, D, Guarna, A, Ley, S, Polara, A, Rodriguez, F
Format:	Journal article
Language:	English
Published:	2002

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