Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.
BACKGROUND: Attenuated familial adenomatous polyposis (AFAP) is associated with germline mutations in the 5', 3', and exon 9 of the adenomatous polyposis coli (APC) gene. These mutations probably encode a limited amount of functional APC protein. METHODS AND RESULTS: We found that colonic...
Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , |
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Médium: | Journal article |
Jazyk: | English |
Vydáno: |
2006
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