The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells

The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells

Disease recurrence following chemotherapy is a major clinical challenge in ovarian cancer (OC), but little is known regarding how the tumour epigenome regulates transcriptional programs underpinning chemoresistance. We determine the single cell chromatin accessibility landscape of omental OC metasta...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Croft, W, Pounds, R, Jeevan, D, Singh, K, Balega, J, Sundar, S, Williams, A, Ganesan, R, Kehoe, S, Ott, S, Zuo, J, Yap, J, Moss, P
التنسيق: Journal article
اللغة:English
منشور في: Nature Research 2024

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