Using neuroimaging to uncover awareness in brain-injured and anesthetized patients
We cast a novel perspective on two distinct populations: patients who become accidentally intraoperatively aware after receiving general anesthesia and severely brain-injured patients who are diagnosed as being in a vegetative state. In both cases, patients are behaviorally non-responsive —and on th...
| Main Authors: | , , , |
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| Format: | Journal article |
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Frontiers in Bioscience
2018
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| _version_ | 1797055504491479040 |
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| author | Graham, M Owen, A Weijer, C Naci, L |
| author_facet | Graham, M Owen, A Weijer, C Naci, L |
| author_sort | Graham, M |
| collection | OXFORD |
| description | We cast a novel perspective on two distinct populations: patients who become accidentally intraoperatively aware after receiving general anesthesia and severely brain-injured patients who are diagnosed as being in a vegetative state. In both cases, patients are behaviorally non-responsive —and on this basis presumed to lack consciousness— yet, retain covert awareness. In both contexts, detecting consciousness is highly challenging, yet highly important for ensuring adequate patient care. Although great strides have been made in the development of depth-of-anesthesia monitors, these monitors have significant limitations. On the other hand, recent neuroimaging studies on severely brain-injured patients have developed neurobiologically-informed markers of conscious awareness that hold potential for improving monitoring of covert awareness during general anesthesia. Further research is required to determine the implementation of these assessments in the surgical context, and this approach provides promising avenues for improved detection of intraoperative awareness and prevention of accidental awareness under general anesthesia. |
| first_indexed | 2024-03-06T19:11:37Z |
| format | Journal article |
| id | oxford-uuid:16f76e0f-2962-418c-9b3a-71c6182ade38 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:11:37Z |
| publishDate | 2018 |
| publisher | Frontiers in Bioscience |
| record_format | dspace |
| spelling | oxford-uuid:16f76e0f-2962-418c-9b3a-71c6182ade382022-03-26T10:34:23ZUsing neuroimaging to uncover awareness in brain-injured and anesthetized patientsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:16f76e0f-2962-418c-9b3a-71c6182ade38Symplectic Elements at OxfordFrontiers in Bioscience2018Graham, MOwen, AWeijer, CNaci, LWe cast a novel perspective on two distinct populations: patients who become accidentally intraoperatively aware after receiving general anesthesia and severely brain-injured patients who are diagnosed as being in a vegetative state. In both cases, patients are behaviorally non-responsive —and on this basis presumed to lack consciousness— yet, retain covert awareness. In both contexts, detecting consciousness is highly challenging, yet highly important for ensuring adequate patient care. Although great strides have been made in the development of depth-of-anesthesia monitors, these monitors have significant limitations. On the other hand, recent neuroimaging studies on severely brain-injured patients have developed neurobiologically-informed markers of conscious awareness that hold potential for improving monitoring of covert awareness during general anesthesia. Further research is required to determine the implementation of these assessments in the surgical context, and this approach provides promising avenues for improved detection of intraoperative awareness and prevention of accidental awareness under general anesthesia. |
| spellingShingle | Graham, M Owen, A Weijer, C Naci, L Using neuroimaging to uncover awareness in brain-injured and anesthetized patients |
| title | Using neuroimaging to uncover awareness in brain-injured and anesthetized patients |
| title_full | Using neuroimaging to uncover awareness in brain-injured and anesthetized patients |
| title_fullStr | Using neuroimaging to uncover awareness in brain-injured and anesthetized patients |
| title_full_unstemmed | Using neuroimaging to uncover awareness in brain-injured and anesthetized patients |
| title_short | Using neuroimaging to uncover awareness in brain-injured and anesthetized patients |
| title_sort | using neuroimaging to uncover awareness in brain injured and anesthetized patients |
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