Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.

HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted CD8+ T-cell responses. Factors that contribute to slow progre...

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Bibliographic Details
Main Authors:	Adland, E, Paioni, P, Thobakgale, C, Laker, L, Mori, L, Muenchhoff, M, Csala, A, Clapson, M, Flynn, J, Novelli, V, Hurst, J, Naidoo, V, Shapiro, R, Huang, K, Frater, A, Prendergast, A, Prado, J, Ndung'u, T, Walker, B, Carrington, M, Jooste, P, Goulder, P
Format:	Journal article
Language:	English
Published:	2015

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