Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping
We herein demonstrate that in the Holstein–Friesian dairy cattle population, microsatellites are as polymorphic on the X chromosome as on the autosomes but that the level of linkage disequilibrium between these markers is higher on the X chromosome than on the autosomes. The latter observation is no...
| Hauptverfasser: | , , , , , |
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| Format: | Journal article |
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Genetics Society of America
2006
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| _version_ | 1826260832164511744 |
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| author | Sandor, C Farnir, F Hansoul, S Coppieters, W Meuwissen, T Georges, M |
| author_facet | Sandor, C Farnir, F Hansoul, S Coppieters, W Meuwissen, T Georges, M |
| author_sort | Sandor, C |
| collection | OXFORD |
| description | We herein demonstrate that in the Holstein–Friesian dairy cattle population, microsatellites are as polymorphic on the X chromosome as on the autosomes but that the level of linkage disequilibrium between these markers is higher on the X chromosome than on the autosomes. The latter observation is not compatible with the small male-to-female ratio that prevails in this population and results in a higher gonosomal than autosomal effective population size. It suggests that the X chromosome undergoes distinct selective or mutational forces. We describe and characterize a novel Markovian approach to exploit this linkage disequilibrium to compute the probability that two chromosomes are identical-by-descent conditional on flanking marker data. We use the ensuing probabilities in a restricted maximum-likelihood approach to search for quantitative trait loci (QTL) affecting 48 traits of importance to the dairy industry and provide evidence for the presence of QTL affecting 5 of these traits on the bovine X chromosome. |
| first_indexed | 2024-03-06T19:11:58Z |
| format | Journal article |
| id | oxford-uuid:17159311-5ca5-4d6f-8539-b56718b7cd70 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:11:58Z |
| publishDate | 2006 |
| publisher | Genetics Society of America |
| record_format | dspace |
| spelling | oxford-uuid:17159311-5ca5-4d6f-8539-b56718b7cd702022-03-26T10:35:00ZLinkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mappingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:17159311-5ca5-4d6f-8539-b56718b7cd70Symplectic Elements at OxfordGenetics Society of America2006Sandor, CFarnir, FHansoul, SCoppieters, WMeuwissen, TGeorges, MWe herein demonstrate that in the Holstein–Friesian dairy cattle population, microsatellites are as polymorphic on the X chromosome as on the autosomes but that the level of linkage disequilibrium between these markers is higher on the X chromosome than on the autosomes. The latter observation is not compatible with the small male-to-female ratio that prevails in this population and results in a higher gonosomal than autosomal effective population size. It suggests that the X chromosome undergoes distinct selective or mutational forces. We describe and characterize a novel Markovian approach to exploit this linkage disequilibrium to compute the probability that two chromosomes are identical-by-descent conditional on flanking marker data. We use the ensuing probabilities in a restricted maximum-likelihood approach to search for quantitative trait loci (QTL) affecting 48 traits of importance to the dairy industry and provide evidence for the presence of QTL affecting 5 of these traits on the bovine X chromosome. |
| spellingShingle | Sandor, C Farnir, F Hansoul, S Coppieters, W Meuwissen, T Georges, M Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping |
| title | Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping |
| title_full | Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping |
| title_fullStr | Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping |
| title_full_unstemmed | Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping |
| title_short | Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping |
| title_sort | linkage disequilibrium on the bovine x chromosome characterization and use in quantitative trait locus mapping |
| work_keys_str_mv | AT sandorc linkagedisequilibriumonthebovinexchromosomecharacterizationanduseinquantitativetraitlocusmapping AT farnirf linkagedisequilibriumonthebovinexchromosomecharacterizationanduseinquantitativetraitlocusmapping AT hansouls linkagedisequilibriumonthebovinexchromosomecharacterizationanduseinquantitativetraitlocusmapping AT coppietersw linkagedisequilibriumonthebovinexchromosomecharacterizationanduseinquantitativetraitlocusmapping AT meuwissent linkagedisequilibriumonthebovinexchromosomecharacterizationanduseinquantitativetraitlocusmapping AT georgesm linkagedisequilibriumonthebovinexchromosomecharacterizationanduseinquantitativetraitlocusmapping |