Coagulation And Metastasis: What Does The Experimental Literature Tell Us?
Inhibition of coagulation greatly limits cancer metastasis in many experimental models. Cancer cells trigger coagulation, through expression of tissue factor or P-selectin ligands that have correlated with worse prognosis in human clinical studies. Cancer cells also affect coagulation through expres...
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1826260839519223808 |
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| author | Gil-Bernabé, A Lucotti, S Muschel, R |
| author_facet | Gil-Bernabé, A Lucotti, S Muschel, R |
| author_sort | Gil-Bernabé, A |
| collection | OXFORD |
| description | Inhibition of coagulation greatly limits cancer metastasis in many experimental models. Cancer cells trigger coagulation, through expression of tissue factor or P-selectin ligands that have correlated with worse prognosis in human clinical studies. Cancer cells also affect coagulation through expression of thrombin and release of microparticles that augment coagulation. In the cancer-bearing host, coagulation facilitates tumour progression through release of platelet granule contents, inhibition of Natural Killer cells and recruitment of macrophages. We are revisiting this literature in the light of recent studies in which treatment of clinical cohorts with anticoagulant drugs led to diminished metastasis. © 2013 John Wiley and Sons Ltd. |
| first_indexed | 2024-03-06T19:12:05Z |
| format | Journal article |
| id | oxford-uuid:171d85a9-13a6-4425-bd96-2d7eb41bc8a5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:12:05Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:171d85a9-13a6-4425-bd96-2d7eb41bc8a52022-03-26T10:35:15ZCoagulation And Metastasis: What Does The Experimental Literature Tell Us?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:171d85a9-13a6-4425-bd96-2d7eb41bc8a5EnglishSymplectic Elements at Oxford2013Gil-Bernabé, ALucotti, SMuschel, RInhibition of coagulation greatly limits cancer metastasis in many experimental models. Cancer cells trigger coagulation, through expression of tissue factor or P-selectin ligands that have correlated with worse prognosis in human clinical studies. Cancer cells also affect coagulation through expression of thrombin and release of microparticles that augment coagulation. In the cancer-bearing host, coagulation facilitates tumour progression through release of platelet granule contents, inhibition of Natural Killer cells and recruitment of macrophages. We are revisiting this literature in the light of recent studies in which treatment of clinical cohorts with anticoagulant drugs led to diminished metastasis. © 2013 John Wiley and Sons Ltd. |
| spellingShingle | Gil-Bernabé, A Lucotti, S Muschel, R Coagulation And Metastasis: What Does The Experimental Literature Tell Us? |
| title | Coagulation And Metastasis: What Does The Experimental Literature Tell Us? |
| title_full | Coagulation And Metastasis: What Does The Experimental Literature Tell Us? |
| title_fullStr | Coagulation And Metastasis: What Does The Experimental Literature Tell Us? |
| title_full_unstemmed | Coagulation And Metastasis: What Does The Experimental Literature Tell Us? |
| title_short | Coagulation And Metastasis: What Does The Experimental Literature Tell Us? |
| title_sort | coagulation and metastasis what does the experimental literature tell us |
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