Increase of mutations associated with SP resistance in Plasmodium falciparum isolates collected during pregnancy in Nanoro, Burkina Faso
Pregnant women are a high risk group forPlasmodium falciparuminfections,which may result in maternalanemia and low birth weight newborns, among other adversebirth outcomes. Intermittent preventive treatment withsulfadoxine-pyrimethamine during pregnancy (IPTp-SP) is widelyimplemented to prevent thes...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Conference item |
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Wiley
2017
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| _version_ | 1797055640206573568 |
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| author | Ruizendaal, E Mens, P Tahita, M Geskus, R Versteeg, I Traore, M Lompo, P Derra, K Scott, S Bradley, J D'Alessandro, U Tinto, H Schallig, H |
| author_facet | Ruizendaal, E Mens, P Tahita, M Geskus, R Versteeg, I Traore, M Lompo, P Derra, K Scott, S Bradley, J D'Alessandro, U Tinto, H Schallig, H |
| author_sort | Ruizendaal, E |
| collection | OXFORD |
| description | Pregnant women are a high risk group forPlasmodium falciparuminfections,which may result in maternalanemia and low birth weight newborns, among other adversebirth outcomes. Intermittent preventive treatment withsulfadoxine-pyrimethamine during pregnancy (IPTp-SP) is widelyimplemented to prevent these negative effects of malaria.However, resistance against SP byP. falciparummay decreaseefficacy of IPTp-SP. Combinations of point mutations in thedhps(codons A437, K540) anddhfrgenes (codons N51, C59,S108) ofP. falciparumare associated with SP resistance.AimTo study the prevalence of SP resistance mutations wasdetermined amongP. falciparumfound in pregnant women andthe general population (GP) from Nanoro, Burkina Faso and theassociation of IPTp-SP dosing and other variables withmutations. |
| first_indexed | 2024-03-06T19:12:39Z |
| format | Conference item |
| id | oxford-uuid:1747d8ed-c4ca-40b6-a36e-70ec5ac4d953 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:12:39Z |
| publishDate | 2017 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:1747d8ed-c4ca-40b6-a36e-70ec5ac4d9532022-03-26T10:36:20ZIncrease of mutations associated with SP resistance in Plasmodium falciparum isolates collected during pregnancy in Nanoro, Burkina FasoConference itemhttp://purl.org/coar/resource_type/c_5794uuid:1747d8ed-c4ca-40b6-a36e-70ec5ac4d953Symplectic Elements at OxfordWiley2017Ruizendaal, EMens, PTahita, MGeskus, RVersteeg, ITraore, MLompo, PDerra, KScott, SBradley, JD'Alessandro, UTinto, HSchallig, HPregnant women are a high risk group forPlasmodium falciparuminfections,which may result in maternalanemia and low birth weight newborns, among other adversebirth outcomes. Intermittent preventive treatment withsulfadoxine-pyrimethamine during pregnancy (IPTp-SP) is widelyimplemented to prevent these negative effects of malaria.However, resistance against SP byP. falciparummay decreaseefficacy of IPTp-SP. Combinations of point mutations in thedhps(codons A437, K540) anddhfrgenes (codons N51, C59,S108) ofP. falciparumare associated with SP resistance.AimTo study the prevalence of SP resistance mutations wasdetermined amongP. falciparumfound in pregnant women andthe general population (GP) from Nanoro, Burkina Faso and theassociation of IPTp-SP dosing and other variables withmutations. |
| spellingShingle | Ruizendaal, E Mens, P Tahita, M Geskus, R Versteeg, I Traore, M Lompo, P Derra, K Scott, S Bradley, J D'Alessandro, U Tinto, H Schallig, H Increase of mutations associated with SP resistance in Plasmodium falciparum isolates collected during pregnancy in Nanoro, Burkina Faso |
| title | Increase of mutations associated with SP resistance in Plasmodium falciparum isolates collected during pregnancy in Nanoro, Burkina Faso |
| title_full | Increase of mutations associated with SP resistance in Plasmodium falciparum isolates collected during pregnancy in Nanoro, Burkina Faso |
| title_fullStr | Increase of mutations associated with SP resistance in Plasmodium falciparum isolates collected during pregnancy in Nanoro, Burkina Faso |
| title_full_unstemmed | Increase of mutations associated with SP resistance in Plasmodium falciparum isolates collected during pregnancy in Nanoro, Burkina Faso |
| title_short | Increase of mutations associated with SP resistance in Plasmodium falciparum isolates collected during pregnancy in Nanoro, Burkina Faso |
| title_sort | increase of mutations associated with sp resistance in plasmodium falciparum isolates collected during pregnancy in nanoro burkina faso |
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