| Summary: | <p><strong>Chapter 1</strong><br>
The major synthetic studies towards (–)-clausenamide and its analogues are reviewed. The significance of C–H functionalisation and various aspects of the application of cytochrome P450<sub>BM3</sub> enzymes are discussed.</p>
<br>
<p><strong>Chapter 2</strong><br>
The chemical syntheses of six target lactams: diphenyl-derived <em>cis-</em> and <em>trans-</em>lactams, indene-derived lactam, phenalene-derived lactam, and phenalene-derived <em>cis-</em> and <em>trans-</em>isomer lactams are described.</p>
<br>
<p><strong>Chapter 3</strong><br>
The range of metabolites obtained from hydroxylation of the six target lactams by P450<sub>BM3</sub> variants are discussed, with a focus on the benzylic alcohols. Strategies to access the clausenamide analogues shown below are validated.</p>
|
|---|