The role of radiotherapy in multimodal treatment of pancreatic carcinoma.
Pancreatic ductal carcinoma is one of the most lethal malignancies, but in recent years a number of positive developments have occurred in the management of pancreatic carcinoma. This article aims to give an overview of the current knowledge regarding the role of radiotherapy in the treatment of pan...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826260920694734848 |
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| author | Brunner, T Scott-Brown, M |
| author_facet | Brunner, T Scott-Brown, M |
| author_sort | Brunner, T |
| collection | OXFORD |
| description | Pancreatic ductal carcinoma is one of the most lethal malignancies, but in recent years a number of positive developments have occurred in the management of pancreatic carcinoma. This article aims to give an overview of the current knowledge regarding the role of radiotherapy in the treatment of pancreatic ductal adenocarcinoma (PDAC). The results of meta-analyses, phase III-studies, and phase II-studies using chemoradiotherapy and chemotherapy for resectable and non-resectable PDAC were reviewed. The use of radiotherapy is discussed in the neoadjuvant and adjuvant settings as well as in the locally advanced situation. Whenever possible, radiotherapy should be performed as simultaneous chemoradiotherapy. Patients with PDAC should be offered entry into clinical trials to identify optimal treatment results. |
| first_indexed | 2024-03-06T19:13:23Z |
| format | Journal article |
| id | oxford-uuid:178a318c-a8d4-46e4-8ac3-d95aa9613809 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:13:23Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:178a318c-a8d4-46e4-8ac3-d95aa96138092022-03-26T10:37:51ZThe role of radiotherapy in multimodal treatment of pancreatic carcinoma.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:178a318c-a8d4-46e4-8ac3-d95aa9613809EnglishSymplectic Elements at Oxford2010Brunner, TScott-Brown, MPancreatic ductal carcinoma is one of the most lethal malignancies, but in recent years a number of positive developments have occurred in the management of pancreatic carcinoma. This article aims to give an overview of the current knowledge regarding the role of radiotherapy in the treatment of pancreatic ductal adenocarcinoma (PDAC). The results of meta-analyses, phase III-studies, and phase II-studies using chemoradiotherapy and chemotherapy for resectable and non-resectable PDAC were reviewed. The use of radiotherapy is discussed in the neoadjuvant and adjuvant settings as well as in the locally advanced situation. Whenever possible, radiotherapy should be performed as simultaneous chemoradiotherapy. Patients with PDAC should be offered entry into clinical trials to identify optimal treatment results. |
| spellingShingle | Brunner, T Scott-Brown, M The role of radiotherapy in multimodal treatment of pancreatic carcinoma. |
| title | The role of radiotherapy in multimodal treatment of pancreatic carcinoma. |
| title_full | The role of radiotherapy in multimodal treatment of pancreatic carcinoma. |
| title_fullStr | The role of radiotherapy in multimodal treatment of pancreatic carcinoma. |
| title_full_unstemmed | The role of radiotherapy in multimodal treatment of pancreatic carcinoma. |
| title_short | The role of radiotherapy in multimodal treatment of pancreatic carcinoma. |
| title_sort | role of radiotherapy in multimodal treatment of pancreatic carcinoma |
| work_keys_str_mv | AT brunnert theroleofradiotherapyinmultimodaltreatmentofpancreaticcarcinoma AT scottbrownm theroleofradiotherapyinmultimodaltreatmentofpancreaticcarcinoma AT brunnert roleofradiotherapyinmultimodaltreatmentofpancreaticcarcinoma AT scottbrownm roleofradiotherapyinmultimodaltreatmentofpancreaticcarcinoma |