Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease.

BACKGROUND: Vitamin D insufficiency has been implicated in autoimmunity. ChIP-seq experiments using immune cell lines have shown that vitamin D receptor (VDR) binding sites are enriched near regions of the genome associated with autoimmune diseases. We aimed to investigate VDR binding in primary CD...

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Detalhes bibliográficos
Main Authors: Handel, A, Sandve, G, Disanto, G, Berlanga-Taylor, A, Gallone, G, Hanwell, H, Drabløs, F, Giovannoni, G, Ebers, G, Ramagopalan, S, Price, R
Formato: Journal article
Idioma:English
Publicado em: BioMed Central 2013